Liu, Wei; Lavagnino, Marissa N.; Gould, Colin A.; Alcazar, Jesus; MacMillan, David W. C. published the artcile< A biomimetic SH2 cross-coupling mechanism for quaternary sp3-carbon formation>, Related Products of 6482-24-2, the main research area is ester alkyl bromide photoredox cross coupling iron.
Bimol. homolytic substitution (SH2) is an open-shell mechanism that is implicated across a host of biochem. alkylation pathways. Surprisingly, however, this radical substitution manifold has not been generally deployed as a design element in synthetic C-C bond formation. Authors found that the SH2 mechanism can be leveraged to enable a biomimetic sp3-sp3 cross-coupling platform that furnishes quaternary sp3-carbon centers, a long-standing challenge in organic mol. construction. This heteroselective radical-radical coupling uses the capacity of iron porphyrin to readily distinguish between the SH2 bond-forming roles of open-shell primary and tertiary carbons, combined with photocatalysis to generate both radical classes simultaneously from widely abundant functional groups. Mechanistic studies confirm the intermediacy of a primary alkyl-Fe(III) species prior to coupling and provide evidence for the SH2 displacement pathway in the critical quaternary sp3-carbon bond formation step.
Science (Washington, DC, United States) published new progress about Bromoalkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Related Products of 6482-24-2.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem