Zhu, Yuchao; Zhang, Ziyao; Jin, Rui; Liu, Jianzhong; Liu, Guoquan; Han, Bing; Jiao, Ning published the artcile< DMSO-Enabled Selective Radical O-H Activation of 1,3(4)-Diols>, Quality Control of 6482-24-2, the main research area is diol silver DMSO aryl migration catalyst; ether keto preparation; DMSO; alkoxyl radicals; cleavage reactions; selectivity; silver.
Control of selectivity is one of the central topics in organic chem. Although unprecedented alkoxyl-radical-induced transformations have drawn a lot of attention, compared to selective C-H activation, selective radical O-H activation remains less explored. Herein, we report a novel selective radical O-H activation strategy of diols by combining spatial effects with proton-coupled electron transfer (PCET). It was found that DMSO is an essential reagent that enables the regioselective transformation of diols. Mechanistic studies indicated the existence of the alkoxyl radical and the selective interaction between DMSO and hydroxyl groups. Moreover, the distal C-C cleavage was realized by this selective alkoxyl-radical-initiation protocol.
Angewandte Chemie, International Edition published new progress about Aliphatic alcohols, radicals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Quality Control of 6482-24-2.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem