In 2022,Zhao, Yanliang; Wang, Honglei; Wu, Naiwei; Yang, Junxia; Sun, Jikai; Zhai, Dong; Deng, Weiqiao published an article in International Journal of Quantum Chemistry. The title of the article was 《The mechanism of sugar produced from simple glycolaldehyde derivative at ambient conditions》.Recommanded Product: 2-(Benzyloxy)acetaldehyde The author mentioned the following in the article:
A benchmark of sugar produced from simple glycolaldehyde derivative has been achieved at ambient conditions (Science, 2004, 305, 1752), which is the most important step to produce life in nature. However, the mechanism has never been clearly understood. Here, we report a reaction mechanism which includes a two-step synthesis of sugars by selective aldol reactions based on the d. functional theory (DFT) calculations Results show that the prochirality of attacking orientation of the enamine intermediate and steric effect in proton transfer is the main cause for stereochem. preference. This work provides the theor. insight of sugar produced in glycolaldehyde procedure and may assist the improvement of catalyst design for this procedure. After reading the article, we found that the author used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Recommanded Product: 2-(Benzyloxy)acetaldehyde)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Recommanded Product: 2-(Benzyloxy)acetaldehyde
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem