In 2019,Angewandte Chemie, International Edition included an article by Todorovic, Mihajlo; Schwab, Katerina D.; Zeisler, Jutta; Zhang, Chengcheng; Benard, Francois; Perrin, David M.. Reference of 2-(Benzyloxy)acetaldehyde. The article was titled 《Fluorescent isoindole crosslink (FlICk) chemistry: A rapid, user-friendly stapling reaction》. The information in the text is summarized as follows:
The stabilization of peptide secondary structure via stapling is a ubiquitous goal for creating new probes, imaging agents, and drugs. Inspired by indole-derived crosslinks found in natural peptide toxins, we employed ortho-phthalaldehydes to create isoindole staples, thus transforming inactive linear and monocyclic precursors into bioactive monocyclic and bicyclic products. Mild, metal-free conditions give an array of macrocyclic α-MSH (α-MSH) derivatives, of which several isoindole-stapled α-MSH analogs (Ki ≈ 1 nM) are found to be as potent as α-MSH. Analogously, late-stage intra-annular isoindole stapling furnished a bicyclic peptide mimic of α-amanitin that is cytotoxic to CHO cells (IC50=70 μM). Given its user-friendliness, we have termed this approach FlICk (fluorescent isoindole crosslink) chem. In the experimental materials used by the author, we found 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Reference of 2-(Benzyloxy)acetaldehyde)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Reference of 2-(Benzyloxy)acetaldehyde
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem