Swathi, G.; Deepthi, G.; Visakh, Deepthi; Prathyusha, J.; Fatima, Nafees; lakshmi, M. Sai published their research in Indo American Journal of Pharmaceutical Sciences in 2021. The article was titled 《Development and validation for estimation of clindamycin, adapalene and sofosbuvir in bulk and pharmaceutical dosage forms by rp-hplc method》.HPLC of Formula: 106685-40-9 The article contains the following contents:
A simple, accurate, rapid and precise isocratic stability indicating reversed-phase high-performance liquid chromatog. method has been developed and validated for simultaneous determination of Clindamycin and Adapalene in tablets. The chromatog. separation was carried out on C18 BDS Hypersil (150 × 4.6mm, 5μ) with a mixture ofmixed phosphate buffer : acetonitrile (55:45%volume/volume) as a mobile phase at a flow rate of 1.0mL/min. UV detection was performed at 230nm. The retention times were2.84 and 3.999min for Clindamycin and Adapalene resp. Calibration plots were linear (r2 = 0.999) over the concentration range of 25-150μg/mL for Clindamycin and 2.5-15μg/mL for Adapalene. The method was validated for accuracy, precision, specificity, linearity and sensitivity. The proposed method was successfully used for quant. anal. of tablets. No interference from any component of pharmaceutical dosage form was observed Validation studies revealed that method is specific, rapid, reliable, and reproducible. The high recovery and low relative standard deviation confirm the suitability of the method for routine determination of Clindamycin and Adapalene in bulk and tablet dosage form. Sofosbuvir is used primarily to treat hepatitis C and viral hemorrhagic fevers. It is possible to select a sofosbuvir resistant mutant of HCV that can replicate to levels similar to wild type virus grown without sofosbuvir. Anal. of the mutations responsible for the sofosbuvir resistance may aid in understanding the mechanism of action of sofosbuvir. The results came from multiple reactions, including the reaction of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9HPLC of Formula: 106685-40-9)
6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.HPLC of Formula: 106685-40-9
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