In 2019,Applied Microbiology and Biotechnology included an article by Kannappan, Arunachalam; Srinivasan, Ramanathan; Nivetha, Arumugam; Annapoorani, Angusamy; Pandian, Shunmugiah Karutha; Ravi, Arumugam Veera. Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde. The article was titled 《Anti-virulence potential of 2-hydroxy-4-methoxybenzaldehyde against methicillin-resistant Staphylococcus aureus and its clinical isolates》. The information in the text is summarized as follows:
Burgeoning antibiotic resistance among bacterial pathogens necessitates the alternative treatment options to control the multidrug-resistant bacterial infections. Plant secondary metabolites, a significant source of structurally diverse compounds, posses several biol. activities. The present study was designed to investigate the anti-virulence potential of least explored phytocompound 2-hydroxy-4-methoxybenzaldehyde (HMB) against methicillin-resistant Staphylococcus aureus (MRSA) and its clin. isolates. The min. inhibitory concentration of HMB was found to be 1024 μg/mL. HMB at sub-MIC (200 μg/mL) exhibited a profound staphyloxanthin inhibitory activity against MRSA and its clin. isolates. Besides, growth curve anal. revealed the non-bactericidal activity of HMB at its sub-MIC. Other virulences of MRSA such as lipase, nuclease, and hemolysin were also significantly inhibited upon HMB treatment. The observations made out of blood and H2O2 sensitivity assay suggested that HMB treatment sensitized the test pathogens and aided the functions of host immune responses. Transcriptomic anal. revealed that HMB targets the virulence regulatory genes such as sigB and saeS to attenuate the production of virulence arsenal in MRSA. Further, the result of in vitro cytotoxicity assay using PBMC cells portrayed the non-toxic nature of HMB. To our knowledge, for the first time, the present study reported the virulence inhibitory property of HMB against MRSA along with plausible mol. mechanisms. Addnl. studies incorporating in vivo anal. and omics technologies are required to explore the anti-virulence potential of HMB and its mode of action during MRSA infections. In addition to this study using 2-Hydroxy-4-methoxybenzaldehyde, there are many other studies that have used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde) was used in this study.
2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde
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