In 2019,Angewandte Chemie, International Edition included an article by Goetzke, F. Wieland; Mortimore, Mike; Fletcher, Stephen P.. Reference of 3-Methoxyphenylboronic acid. The article was titled 《Enantio- and Diastereoselective Suzuki-Miyaura Coupling with Racemic Bicycles》. The information in the text is summarized as follows:
A rhodium-catalyzed enantio- and diastereoselective Suzuki-Miyaura cross-coupling between racemic fused bicyclic allylic chlorides, e.g., I and boronic acids RB(OH)2 (R = naphth-2-yl, thiophen-3-yl, 2H-1,3-benzodioxol-5-yl, etc.) has been described. The highly stereoselective transformation allows for the coupling of aryl, heteroaryl, and alkenyl boronic acids and gives access to functionalized bicyclic cyclopentenes, e.g., II which can be converted into other five-membered-ring scaffolds with up to five contiguous stereocenters. Preliminary mechanistic studies suggest that these reactions occur with overall retention of the relative stereochem. and are enantioconvergent for pseudo-sym. allylic chloride starting materials. In addition, a bicyclic allylic chloride starting material without pseudo-symmetry undergoes a highly enantioselective regiodivergent reaction. After reading the article, we found that the author used 3-Methoxyphenylboronic acid(cas: 10365-98-7Reference of 3-Methoxyphenylboronic acid)
3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Reference of 3-Methoxyphenylboronic acid
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