In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Gao, Qianwen; Liu, Ze-Shui; Hua, Yu; Li, Lisha; Cheng, Hong-Gang; Cong, Hengjiang; Zhou, Qianghui. Application of 529-28-2. The article was titled 《A palladium/norbornene cooperative catalysis to access N-containing bridged scaffolds》. The information in the text is summarized as follows:
A palladium/norbornene cooperative catalysis promoted annulation involving an ortho-C-H amination and intramol. Heck cascade between aryl iodides ArI (Ar = 2-methylphenyl, 3-fluoro-2-methylphenyl, naphthalen-1-yl, etc.) and functionalized amination reagents I (R = Me, Et, benzyl, cyclopropylmethyl, 2-methylpropyl) is reported, thereby providing a highly convergent access to the unique N-containing bridged scaffolds: hexahydro-2,6-methano-1-benzazocine II (R1 = Me, F, C6H5, etc.; R2 = H, Me, F; R3 = H, F, C(O)2CH3, etc.; R1R2 = CH=CH-CH=CH). The salient features of the reaction include its broad substrate scope (with respect to aryl iodides), its high step economy, and good chemoselectivity. Preliminary studies underscore the future promise of rendering this Catellani-type annulation enantioselective.1-Iodo-2-methoxybenzene(cas: 529-28-2Application of 529-28-2) was used in this study.
1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Application of 529-28-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem