《Attenuation of Proteus mirabilis colonization and swarming motility on indwelling urinary catheter by antibiofilm impregnation: An in vitro study》 was written by Durgadevi, Ravindran; Kaleeshwari, Ramaiah; Swetha, Thirukannamangai Krishnan; Alexpandi, Rajaiah; Karutha Pandian, Shunmugaiah; Veera Ravi, Arumugam. Product Details of 673-22-3 And the article was included in Colloids and Surfaces, B: Biointerfaces in 2020. The article conveys some information:
Proteus mirabilis is one of the important etiol. agents of urinary tract infections (UTI), which complicates the long-term urinary catheterization process in clin. settings. Owing to its crystalline biofilm forming ability and flagellar motility, elimination of P. mirabilis from urinary system becomes very difficult. Thus, the present study is focused to prepare antibiofilm-impregnated Silicone Foley Catheter (SFC) to prevent P. mirabilis instigated UTIs. Through solvent swelling method, the antibiofilm compounds such as linalool (LIN) and 2-hydroxy-4-methoxy benzaldehyde (HMB) were successfully infused into SFCs. Surface topog. was studied using AFM anal., which unveiled the unmodified surface roughness of normal and antibiofilm-impregnated SFCs. In addition, UV-spectrometric and FT-IR analyses revealed good impregnation efficacy and prolonged stability of antibiofilm compounds Further, in vitro biofilm biomass quantification assay exhibited a maximum of 87% and 84% crystalline biofilm inhibition in LIN (350μg/cm3) and HMB (120μg/cm3) impregnated SFCs, resp. against P. mirabilis in artificial urine medium. Also, the LIN & HMB-impregnated SFCs demonstrated long-term crystalline biofilm inhibitory activity for more than 30 days, which is ascribed to the sustained release of the compounds Furthermore, the results of swarming motility anal. revealed the efficacy of antibiofilm-impregnated catheters to mitigate the migration of pathogens over them. Thus, antibiofilm-impregnated catheter is proposed to act as a suitable strategy for reducing P. mirabilis infections and associated complications in longterm urinary catheter users. The results came from multiple reactions, including the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Product Details of 673-22-3)
2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Product Details of 673-22-3
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