Ding, Decai; Dong, Haiyan; Wang, Chuan published the artcile< Nickel-Catalyzed Asymmetric Domino Ring Opening/Cross-Coupling Reaction of Cyclobutanones via a Reductive Strategy>, Quality Control of 6482-24-2, the main research area is chiral indanone preparation enantioselective; cyclobutanone alkylbromide ring opening tandem coupling reduction nickel catalyst; Catalysis; Organic Reaction; Organic Synthesis.
The successful application of reductive strategy in the asym. domino ring opening/cross-coupling reaction of prochiral cyclobutanones I (R = Me, Et, n-Pr; R1 = H, Me, F, etc.; R2 = H, Me, OCH3) was demonstrated. Under the catalysis of a chiral nickel complex, various aryl iodide-tethered cyclobutanones I were reacted with alkyl bromides R3Br (R3 = 2-methoxyethyl, cyclopentyl, oxan-4-yl, etc.) as the electrophilic coupling partner, providing a variety of chiral indanones II bearing a quaternary stereogenic center in highly enantioselective manner, which can be further converted to diverse benzene-fused cyclic compounds including III, IV, V (X = O, NH). The preliminary mechanistic investigations support a mechanism involving Ni(I)-mediated enantiotopic C-C σ-bond activation of cyclobutanones as key elementary step in the catalytic cycle.
iScience published new progress about Bond activation catalysts (C-C). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Quality Control of 6482-24-2.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem