Cano, Carolina; Paez, Juan Antonio; Goya, Pilar; Serrano, Antonia; Pavon, Javier; Rodriguez de Fonseca, Fernando; Suardiaz, Margarita; Martin, Maria Isabel published the artcile< Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide>, Recommanded Product: n-Propylsulphamoyl chloride, the main research area is anandamide sulfamide derivative preparation CB1 receptor affinity structure activity.
Arachidonyl and linoleyl sulfamide derivatives have been synthesized and their potential cannabimimetic properties evaluated in in vitro functional and binding assays. Replacement of the ethanolamide moiety of anandamide by -CH2NHSO2NH-R (R = saturated or unsaturated long chain alkyl, adamantyl derivative) considerably reduces the CB1 receptor activity and only some of the compounds showed modest cannabinoid properties in binding assays. The new compounds were also tested as inhibitors of the FAAH enzyme but were inactive.
European Journal of Medicinal Chemistry published new progress about Cannabinoid receptor 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Recommanded Product: n-Propylsulphamoyl chloride.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem