Yu, Jianjin; Li, Chao-Jun; Zeng, Huiying published the artcile< Dearomatization-Rearomatization Strategy for ortho-Selective Alkylation of Phenols with Primary Alcohols>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is palladium catalyzed ortho selective alkylation phenol alc dearomatization rearomatization; aromaticity; cross-coupling; palladium; reaction mechanisms; synthetic methods.
Phenols are common precursors and core structures of a variety of industrial chems. ranging from pharmaceuticals to polymers. However, the synthesis of site-specifically substituted phenols is challenging, and thus the development of new methods for this purpose would be highly desirable. Reported here is a protocol for palladium-catalyzed ortho-selective alkylation reactions of phenols with primary alcs. by a dearomatization-rearomatization strategy, with water as the sole byproduct. Various substituted phenols and primary alcs. were compatible with the standard reaction conditions. The detailed mechanism of this transformation was also investigated.
Angewandte Chemie, International Edition published new progress about Alkylation. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem