《Simultaneous estimation of dapsone and adapalene in gel formulation by UV- spectroscopy》 was published in International Journal of Pharmaceutical Sciences and Research in 2020. These research results belong to Vichare, V. S.; Handargule, P. V.. Reference of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid The article mentions the following:
A new, simple, sensitive, and economical UV spectro-photometric method was developed for the simultaneous anal. of Adapalene and Dapsone in pharmaceutical formulation. This UV method was developed with THF and Distilled water as solvents. The wavelengths selected for anal. in the present method were 237 nm and 293 nm. The method was validated as per ICH guidelines. The method was validated for linearity, accuracy, precision, specificity and robustness. Linearity was found to be within the concentration range of 0.05-0.25μg/mL for Adapalene and 2.5-12.5μg/mL for Dapsone. Accuracy for the method was determined by recovery studies. The % drug recovered was found to be 99-102% weight/weight The % RSD values of repeatability and intermediate precision were found to be less than 2, providing method was precise in nature. From all these studies it was observed that there was no interference of excipients from the formulation during the anal. The advantages of this method for anal. purposes lie in the rapid determination, its cost-effectiveness, easy preparation of the sample and good reproducibility. In addition to this, the present method can be recommended for the simultaneous determination of Adapalene and Dapsone in routine quality control anal. in combined drug formulations. In addition to this study using 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid, there are many other studies that have used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Reference of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid) was used in this study.
6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Reference of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid
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