《Establishment of a Monoclonal Antibody That Recognizes Cysteine-Rich Domain 1 of Human CD271》 was written by Morita, Shinkichi; Mochizuki, Mai; Shibuya-Takahashi, Rie; Nakamura-Shima, Mao; Yamazaki, Tomoko; Imai, Takayuki; Asada, Yukinori; Matsuura, Kazuto; Kawamura, Sadafumi; Yamaguchi, Kazunori; Yasuda, Jun; Sugamura, Kazuo; Katori, Yukio; Satoh, Kennichi; Tamai, Keiichi. Category: ethers-buliding-blocks And the article was included in Monoclonal Antibodies in Immunodiagnosis and Immunotherapy in 2020. The article conveys some information:
CD271 is a common receptor for all neurotrophins that is localized to neurons, endothelial cells, and the basal layer of the epithelium in normal tissue. Recently, we and others reported that CD271 plays essential roles in the development of squamous cell carcinoma, especially in tumor-initiating cells. Since little is known about how CD271 regulates cancer cell initiation and proliferation, antibodies that recognize different domains of CD271 are needed to enable investigation. Therefore, this study aimed to develop an antihuman CD271 antibody by immunizing mice with a CD271 antigen produced by a baculovirus. The antibody was named hCD271mAb#13, and it recognized cysteine-rich domain 1 with a higher affinity than the com. available antibody ME20.4. We determined that hCD271mAb#13 is suitable for flow cytometry, Western blotting, immunocytochem., and immunohistochem. of formalin-fixed paraffin-embedded tissue. Use of hCD271mAb#13 for CD271 labeling could enable detailed analyses of cancer cell regulation and other biol. processes.6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Category: ethers-buliding-blocks) was used in this study.
6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Category: ethers-buliding-blocks
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