Ma, Jiaoli; Li, Jing; Guo, Penghu; Liao, Xincheng; Cheng, Huicheng published the artcile< Synthesis and antitumor activity of novel indole derivatives containing α-aminophosphonate moieties>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is aminophosphonate moiety indole derivative antitumor activity.
A series of novel indole derivatives containing α-aminophosphonate moieties were synthesized as antitumor agents. The in vitro cytotoxic activity of the compounds was evaluated against human hepatoma cells (HepG2) and human gastric cancer cells (MGC-803) by MTT assay, revealing that most of target compounds exhibited moderate to high antitumor activities. Among them, compound C5 (IC50 = 34.2 μM) demonstrated superior inhibitory activities against HepG2 compared with 5-fluorouracil (IC50 = 78.7 μM). It is noteworthy that compound B7 (IC50 = 35.7 μM) displayed higher inhibitory activities against MGC-803 than that of 5-fluorouracil (IC50 = 82.0 μM).
Arabian Journal of Chemistry published new progress about Antiproliferative agents. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem