Henley-Smith, Peter; Whiting, Donald A.; Wood, Andrew F. published the artcile< Methods for the construction of linear 1,7-diarylheptanoids; synthesis of di-O-methylcentrolobol and precursors (synthetic and biosynthetic) to the meta,meta-bridged biphenyls myricanol and myricanone>, Application In Synthesis of 52244-70-9, the main research area is heptanoid diaryl; arylheptanoid; centrolobol analog; myricanol open chain analog; myricanone open chain analog; Grignard reaction phenylpropanal arylhaloalkane; propanal phenyl Grignard reaction; oxazine salt Grignard reaction; dithiane lithiation diarylheptanoid.
Grignard couplings of arylhaloalkanes with arylpropanals or oxazonium salts and the reactions of arylhaloalkanes with lithiated dithianes were used to prepare 1,7-diarylheptanoids, including synthetic and biosynthetic precursors of meta,meta-bridged biphenyls and related macrocyclic ethers. Thus, 4-(2-benzyloxy-3,4-dimethoxy)-1-bromobutane was treated with Mg and the product was treated with 4-PhCH2OC6H4(CH2)2CHO to give the desired alc. I (X = H, OH; R = R3 = OCH2Ph, R1 = R2 = OMe). Similarly, 4-MeOC6H4(CH2)4Br was treated with Mg and the Grignard reagent produced was treated with the oxazine salt II to give the desired ketone I (X = O, R = R1 = H, R2 = R3 = OMe). 4-(2,3,4-Trimethoxyphenyl)-1-iodobutane reacted with lithiated 2-[2-(p-methoxyphenyl)ethyl]-1,3-dithiane to give after oxidation the desired ketone I (X = O, R = R1 = R2 = R3 = OMe).
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Alcohols Role: USES (Uses). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem