HPLC of Formula: 106685-40-9In 2020 ,《Solid lipid microparticles for hair follicle targeting of adapalene and benzoyl peroxide – Release through targeted erosion》 was published in Journal of Drug Delivery Science and Technology. The article was written by Brammann, Christoph; Bornemann, Christel; Kannewurf, Ramon; Mueller-Goymann, Christel C.. The article contains the following contents:
Sebum-dependent targeting of the upper hair follicle by solid lipid microparticles has been demonstrated for retinoids using adapalene as an example. An extension of this formulation principle to the combination of adapalene/benzoyl peroxide was achieved on the basis of congealed solid-in-oil dispersions of nanoparticulate benzoyl peroxide, which were incorporated into the solid lipid microparticles. To investigate the dermal distribution and release behavior of the solid lipid microparticles after application, fluorescence microscopic ex vivo studies on porcine ear skin samples treated with the exptl. vehicle were supplemented by calorimetric skin lipid interaction studies and release experiments on lipid-coated membranes, investigating the influence of sebum and stratum corneum lipids on the solid lipid microparticle matrix. Fluorescent microscopic images of the treated skin confirm the observation of preferential deposition in the upper hair follicle. In addition, the release experiments show a sebum-dependent release of the active ingredients, with no detectable release in the presence of stratum corneum lipids. The observed discrepancy is probably a result of the rapid disintegration of the particles on contact with sebum, as calorimetric investigations suggest. This behavior, which is based on the similarity between the sebum components and the lipid matrix, allows a targeted release into sebum and thus increased follicular penetration. In addition to this study using 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid, there are many other studies that have used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9HPLC of Formula: 106685-40-9) was used in this study.
6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.HPLC of Formula: 106685-40-9
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