Bowles, Mark R.; Eyles, Darryl W.; Hampson, Edith C. G. M.; Pond, Susan M. published the artcile< Quantitation of paraquat in biological samples by radioimmunoassay using a monoclonal antibody>, HPLC of Formula: 52244-70-9, the main research area is paraquat determination biol sample monoclonal antibody; RIA paraquat urine blood bronchoalveolar lavage.
The authors have developed a sensitive and specific RIA for the quant. determination of paraquat in plasma, urine, and bronchoalveolar lavage fluid using a monoclonal antibody. The synthesis of the iodinated paraquat tracer is novel and less complicated than a previously reported method. Regardless of the type of biol. sample analyzed, the sensitivity of the assay was 0.46 ng/mol in a 200-μL aliquot. The results correlated well with those of another assay performed in a sep. laboratory Paraquat concentrations were determined in plasma and in urine of a dog over several days after the i.v. administration of 7.48 mg paraquat cation/kg and in bronchoalveolar lavage fluid obtained 34 h after the 2-h infusion was discontinued. Concentrations of paraquat measured ranged from 14.1 to 0.03 μg/mL in plasma and 2034 to 0.36 μg/mL in urine. Concentrations of paraquat in plasma obtained at various times after the ingestion of paraquat by three patients ranged from 51.0 to 0.010 μg/mL.
Fundamental and Applied Toxicology published new progress about Alveolus. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, HPLC of Formula: 52244-70-9.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem