Xin, Zhili; Himmelbauer, Martin K.; Jones, J. Howard; Enyedy, Istvan; Gilfillan, Rab; Hesson, Thomas; King, Kristopher; Marcotte, Douglas J.; Murugan, Paramasivam; Santoro, Joseph C.; Gonzalez-Lopez de Turiso, Felix published the artcile< Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors>, Computed Properties of 6482-24-2, the main research area is preparation CNS penetrant apoptosis signal regulating kinase inhibitor.
Apoptosis signal-regulating kinase 1 (ASK1) is a key mediator in the apoptotic and inflammatory cellular stress response. To investigate the therapeutic value of modulating this pathway in neurol. disease, we have completed medicinal chem. studies to identify novel CNS-penetrant ASK1 inhibitors starting from peripherally restricted compounds reported in the literature. This effort led to the discovery of 21, a novel ASK1 inhibitor with good potency (cell IC50 = 138 nM), low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat Kp,uu = 0.38).
ACS Medicinal Chemistry Letters published new progress about Apoptosis. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Computed Properties of 6482-24-2.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem