Rianjongdee, Francesco; Atkinson, Stephen J.; Chung, Chun-wa; Grandi, Paola; Gray, James R. J.; Kaushansky, Laura J.; Medeiros, Patricia; Messenger, Cassie; Phillipou, Alex; Preston, Alex; Prinjha, Rab K.; Rioja, Inmaculada; Satz, Alexander L.; Taylor, Simon; Wall, Ian D.; Watson, Robert J.; Yao, Gang; Demont, Emmanuel H. published the artcile< Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit>, Name: 1,3-Dimethoxypropan-2-amine, the main research area is epigenetics chem probe BET BD2 DNA encoded library bromodomains.
Second-generation bromodomain and extra terminal (BET) inhibitors, which selectively target one of the two bromodomains in the BET proteins, have begun to emerge in the literature. These inhibitors aim to help determine the roles and functions of each domain and assess whether they can demonstrate an improved safety profile in clin. settings compared to pan-BET inhibitors. Herein, we describe the discovery of a novel BET BD2-selective chemotype using a structure-based drug design from a hit identified by DNA-encoded library technologies, showing a structural differentiation from key previously reported greater than 100-fold BD2-selective chemotypes GSK620, GSK046, and ABBV-744. Following a structure-based hypothesis for the selectivity and optimization of the physicochem. properties of the series, we identified 60 (GSK040)(I), an in vitro ready and in vivo capable BET BD2-inhibitor of unprecedented selectivity (5000-fold) against BET BD1, excellent selectivity against other bromodomains, and good physicochem. properties. This novel chem. probe can be added to the toolbox used in the advancement of epigenetics research.
Journal of Medicinal Chemistry published new progress about Bromodomain (BD2). 78531-29-0 belongs to class ethers-buliding-blocks, and the molecular formula is C5H13NO2, Name: 1,3-Dimethoxypropan-2-amine.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem