Reddy, Reddy Rajasekhar; Gudup, Satish Sonbarao; Ghorai, Prasanta published the artcile< Organocatalytic, Enantioselective Synthesis of Cyclohexadienone Containing Hindered Spirocyclic Ethers through an Oxidative Dearomatization/Oxa-Michael Addition Sequence>, Electric Literature of 52244-70-9, the main research area is cyclohexadienone enantioselective preparation spirocyclic ether oxidative dearomatization oxa Michael; asymmetric synthesis; chromans; organocatalysis; oxa-Michael addition; tetrahydrofurans.
An unprecedented enantioselective oxa-Michael reaction of α-tertiary alcs. using cinchona-alkaloid-based chiral bifunctional squaramide catalysts is reported. An oxidative dearomatization of phenol followed by an enantioselective oxa-Michael addition sequence provided a broad array of chiral sterically hindered tetrahydrofurans and tetrahydropyrans attached to a cyclohexadienone moiety in spiro fashion. In general, good yields and excellent enantioselectivities (up to 99 %) were observed The chiral oxo-cycles obtained have easily been transformed into chromans without disturbing the enantioselectivity.
Angewandte Chemie, International Edition published new progress about Dearomatization (oxidative). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Electric Literature of 52244-70-9.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem