Marx, Lisa; Lamberty, Daniel; Choppin, Sabine; Colobert, Francoise; Speicher, Andreas published the artcile< Atroposelective Synthesis of Isoriccardin C through a C-H Activated Heck Type Macrocyclization>, Recommanded Product: 2-(2-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the main research area is atroposelective synthesis isoriccardin C carbon hydrogen activated Heck macrocyclization.
Macrocyclization is typically the key step in syntheses of cyclophane-type natural products. Considering compounds with axially chiral biaryl moieties, the control of atroposelectivity is essential for biol. activity and is synthetically challenging. Herein we report on atroposelective macrocyclization involving an oxidative Heck type process and enabling the first atropo-enantiopure synthesis of (P)-isoriccardin C (I). A chiral sulfinyl auxiliary in the ortho-position of a biaryl axis (still flexible) was used to induce a C-H activated atropodiastereoselective oxidative Heck coupling (>98% de). The traceless character of the sulfinyl auxiliary enables the introduction of a hydroxy group to give the target mol. with >98% ee as well.
European Journal of Organic Chemistry published new progress about Atropisomers. 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Recommanded Product: 2-(2-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem