Huber, Daniela; Loeber, Stefan; Huebner, Harald; Gmeiner, Peter published the artcile< Bivalent molecular probes for dopamine D2-like receptors>, Application of C8H9BrO2, the main research area is arylamidoalkyl substituted phenylpiperazine preparation D2 dopamine receptor structure activity.
Merging two arylamidoalkyl substituted phenylpiperazines as prototypical recognition elements for dopamine D 2-like receptors by oligoethylene glycol linkers led to a series of bivalent ligands. These dimers were investigated in comparison to their monomeric analogs for their dopamine D2long, D2short, D3 and D4 receptor binding. Radioligand binding experiments revealed strong bivalent effects for some para-substituted benzamide derivatives For the D3 subtype, the target compounds showed an up to 70-fold increase of affinity and a substantial enhancement of subtype selectivity when compared to the monovalent analog. Anal. of the binding curves displayed Hill slopes very close to one indicating that the bivalent ligands displace 1 equiv of radioligand. Obviously, the two pharmacophores occupy an orthosteric and an allosteric binding site rather than adopting a receptor-bridging binding mode.
Bioorganic & Medicinal Chemistry published new progress about Dopamine D2 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Application of C8H9BrO2.
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Ether | (C2H5)2O – PubChem