Month: September 2022

Etayo, Pablo et al. published new experimental results with the assistance of cas: 2235-01-0

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Reference of Dimethoxydiphenylmethane

Etayo, Pablo;Badorrey, Ramon;Diaz-de-Villegas, Maria D.;Galvez, Jose A. published 《Chiral Amino Diol Derivatives as New Modular Organocatalysts for the Enantioselective α-Chlorination of Cyclic β-Keto Esters》. The research results were published in《Advanced Synthesis & Catalysis》 in 2010.Reference of Dimethoxydiphenylmethane The article conveys some information:

Highly modular chiral amino diol derivatives, e.g. I, have been used as organocatalysts in the enantioselective α-chlorination of cyclic β-keto esters. Optimization of the catalyst structure and the reaction conditions has allowed the synthesis of optically active α-chlorinated products with high enantioselectivities (up to 96% ee) using inexpensive com. available N-chlorosuccinimide (NCS) as the chlorine source under mild conditions.Dimethoxydiphenylmethane (cas: 2235-01-0) were involved in the experimental procedure.

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Reference of Dimethoxydiphenylmethane

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cas: 2235-01-0 | Ye, Baihuapublished an article in 2012

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Product Details of 2235-01-0

Ye, Baihua;Cramer, Nicolai published 《Chiral Cyclopentadienyl Ligands as Stereocontrolling Element in Asymmetric C-H Functionalization》. The research results were published in《Science (Washington, DC, United States)》 in 2012.Product Details of 2235-01-0 The article conveys some information:

Metal complexes coordinated by a single cyclopentadienyl (Cp) ligand are widely used, versatile catalysts, but their application to asym. reactions has been hindered by the difficulty of designing Cp substituents that effectively bias the coordination sphere. Here, we report on a class of simple C2-sym. Cp derivatives that finely control the spatial arrangement of the transiently coordinated reactants around the central metal atom. Rhodium(III) complexes bearing these ligands proved to be highly enantioselective catalysts for directed carbon-hydrogen (C-H) bond functionalizations of hydroxamic acid derivatives To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Product Details of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of cas: 2235-01-0 | Aepkers, Marion et al. published an article in 2004

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Computed Properties of C15H16O2 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Aepkers, Marion;Wuensch, Bernhard published 《Synthesis and NMDA-receptor affinity of ring and side chain homologous dexoxadrol derivatives》. The research results were published in《Archiv der Pharmazie (Weinheim, Germany)》 in 2004.Computed Properties of C15H16O2 The article conveys some information:

The regioselectivity during transacetalization of benzophenone di-Me acetal with butane-1,2,4-triol is controlled by the reaction conditions. Thermodn. control leads predominantly to the 1,3-dioxolanes whereas kinetic control favors the six-membered acetals. The amines were investigated in receptor binding studies with radioligands for their affinity to the phencyclidine binding site of the NMDA-receptor. In both series the primary amines show the highest NMDA-receptor affinity (Ki = 3.38-1.45 μM). Surprisingly, the piperidine derivative (I) binds with high affinity at σ1-receptors and, therefore, represents a novel lead compound for high affinity σ1-receptor ligands. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Computed Properties of C15H16O2 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zaitsev, Boris A. et al. published new progress in experiments with the help of cas: 2657-87-6

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Recommanded Product: 2657-87-6 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Recommanded Product: 2657-87-6《Novel polycondensation method of improving high-temperature properties of microheterogeneous rolivsan copolymers modified by inserting epoxy and imide bridges between spherical microdomains》 was published in 2017. The authors were Zaitsev, Boris A.;Shvabskaya, Irina D.;Kleptsova, Larisa G., and the article was included in《High Performance Polymers》. The author mentioned the following in the article:

Rolivsan thermosetting resins (ROLs) (low-viscosity solvent-free compositions including (di)vinylarom. ethers and thermosensitive (di)methacrylates) were modified by low amounts of polyfunctional compounds (epoxy resins (ERs) and aromatic diamines (DAs)). Thermochem. transformations in modified ROLs give novel glassy densely cross-linked copolymers with increased high-temperature strength and thermo-oxidative stability. It was revealed that copolymers obtained at different ROLs/ERs and ROLs/DA mixing ratios (which were varied over a wide range) and different heat treatment regimes have various compositions, cross-link densities, chem., topol., and morphol. structures. Structural features of these copolymers were studied by IR spectroscopy, dynamic mech., thermal, and elemental analyses; the temperature dependences of flexural strength were also obtained. Morphol. pattern of the cured ROLs is typical of microheterogeneous polymers where spherical highly cross-linked microdomains (polymer grains) with high Tg are weakly bound by less densely cross-linked defective (intergrain) polymer layers with lower Tg. On the basis of the data obtained in the studies of thermochem. transformations in ROLs/ERs and ROLs/DA blends, the new approach to improving thermal stability and heat resistance of thermosetting resins was developed. We suggest using intergrain layers in microheterogeneous cross-linked polymers as “microreactors” which include target polyfunctional compounds for various high-temperature polymerization and polycondensation reactions. To complete the study, the researchers used 3-(4-Aminophenoxy)aniline (cas: 2657-87-6) .

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Recommanded Product: 2657-87-6 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Choi, Young Chul et al. published new experimental results with the assistance of cas: 2657-87-6

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Application of 2657-87-6 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Choi, Young Chul;Kim, Min Su;Ryu, Kyoung Moon;Lee, Sang Hoon;Jeong, Young Gyu published 《Microstructures and electrothermal characterization of aromatic poly(azomethine ether)-derived carbon films》 in 2020. The article was appeared in 《Journal of Applied Polymer Science》. They have made some progress in their research.Application of 2657-87-6 The article mentions the following:

The authors report the microstructural evolution and electrothermal properties of aromatic poly(azomethine ether) (PAME)-derived C films, which were fabricated by a facile spin-coating and following carbonization at different temperatures of 300-1000°. For the purpose, poly[3-(4-nitrilophenoxy)phenylenenitrilomethine-1,3-phenylenemethine] (mPAME) with a high residue of ∼56.4% after carbonization at 1000° was synthesized for a polymeric precursor for C films. The XPS, Raman spectroscopy, and x-ray diffraction analyses revealed that the mol. structures of mPAME films changed into an intrinsically N-doped graphitic structure, dominantly at the carbonization temperatures of 800-1000°. The elec. conductivity increased considerably from ∼10-7 S/cm, for mPAME-derived films fabricated at 300-700°, to ∼100 S/cm for the film carbonized at 800° to ∼101 S/cm for the films carbonized at 900-1000°. Accordingly, mPAME-derived C films, which were carbonized at 900-1000°, exhibited excellent electrothermal performance, such as rapid temperature responsiveness, high maximum temperatures, and high elec. power efficiency to relatively low applied voltages of 5-13 V. The experimental procedure involved many compounds, such as 3-(4-Aminophenoxy)aniline (cas: 2657-87-6) .

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Application of 2657-87-6 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cas: 2657-87-6 | Jarrahpour, Aliasgharpublished an article in 2015

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Formula: C12H12N2O The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Formula: C12H12N2O《Synthesis of novel mono- and bis-Schiff bases of morpholine derivatives and the investigation of their antimalarial and antiproliferative activities》 was published in 2015. The authors were Jarrahpour, Aliasghar;Shirvani, Pouria;Sharghi, Hashem;Aberi, Mahdi;Sinou, Veronique;Latour, Christine;Brunel, Jean Michel, and the article was included in《Medicinal Chemistry Research》. The author mentioned the following in the article:

A series of new Schiff bases of morpholine were prepared by the reaction of 2-hydroxy-3-(morpholinomethyl)benzaldehyde with several mono- and bis-aromatic amines. All these new compounds were characterized by 1H-NMR, 13C-NMR and IR spectroscopy. They were evaluated as antimalarial agents against P. falciparum K14 strain demonstrating moderate to excellent activities. The IC50 of 6,6′-((1,2-Phenylenebis(azanylylidene))bis(methanylylidene))bis(2-(morpholinomethyl)phenol) was 2.28 μM. Moreover, derivatives present potent antiproliferative activities against U937 leukemia-derived cell line with EC50 values varying from 3 to 8 μM. Finally, due to its quite low cytotoxicity up to 10 μM against normal fibroblast cells, derivative 6,6′-((1,2-Phenylenebis(azanylylidene))bis(methanylylidene))bis(2-(morpholinomethyl)phenol) appeared as a good compromising biol. active product. To complete the study, the researchers used 3-(4-Aminophenoxy)aniline (cas: 2657-87-6) .

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Formula: C12H12N2O The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cas: 2235-01-0 | Thomas, Bejoy et al. made new progress in 2005

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Quality Control of Dimethoxydiphenylmethane The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Thomas, Bejoy;Prathapan, Sreedharan;Sugunan, Sankaran published 《Synthesis of dimethyl acetal of ketones: design of solid acid catalysts for one-pot acetalization reaction》. The research results were published in《Microporous and Mesoporous Materials》 in 2005.Quality Control of Dimethoxydiphenylmethane The article conveys some information:

The synthesis of di-Me acetals of carbonyl compounds such as cyclohexanone, acetophenone, and benzophenone has successfully been carried out by the reaction between ketones and methanol using different solid acid catalysts. The strong influence of the textural properties of the catalysts such as acid amount and adsorption properties (surface area and pore volume) determine the catalytic activity. The mol. size of the reactants and products determine the acetalization ability of a particular ketone. The hydrophobicity of the various rare earth exchanged Mg-Y zeolites, K-10 montmorillonite clay, and cerium exchanged montmorillonite (which shows maximum activity) is more determinant than the number of active sites present on the catalyst. The optimum number of acidic sites as well as dehydrating ability of Ce3+-montmorillonite and K-10 montmorillonite clays and various rare earth exchanged Mg-Y zeolites seem to work well in shifting the equilibrium to the product side. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Quality Control of Dimethoxydiphenylmethane The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adams, Gregory L. team published research on Journal of Medicinal Chemistry in 2022 | 73724-45-5

Product Details of C18H17NO5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., 73724-45-5.

Ethers do have nonbonding electron pairs on their oxygen atoms, 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Product Details of C18H17NO5.

Adams, Gregory L.;Pall, Parul S.;Grauer, Steven M.;Zhou, Xiaoping;Ballard, Jeanine E.;Vavrek, Marissa;Kraus, Richard L.;Morissette, Pierre;Li, Nianyu;Colarusso, Stefania;Bianchi, Elisabetta;Palani, Anandan;Klein, Rebecca;John, Christopher T.;Wang, Deping;Tudor, Matthew;Nolting, Andrew F.;Biba, Mirlinda;Nowak, Timothy;Makarov, Alexey A.;Reibarkh, Mikhail;Buevich, Alexei V.;Zhong, Wendy;Regalado, Erik L.;Wang, Xiao;Gao, Qi;Shahripour, Aurash;Zhu, Yuping;de Simone, Daniele;Frattarelli, Tommaso;Pasquini, Nicolo’ Maria;Magotti, Paola;Iaccarino, Roberto;Li, Yuxing;Solly, Kelli;Lee, Keun-Joong;Wang, Weixun;Chen, Feifei;Zeng, Haoyu;Wang, Jixin;Regan, Hilary;Amin, Rupesh P.;Regan, Christopher P.;Burgey, Christopher S.;Henze, Darrell A.;Sun, Chengzao;Tellers, David M. research published 《 Development of ProTx-II analogs as highly selective peptide blockers of Nav1.7 for the treatment of pain》, the research content is summarized as follows. Inhibitor cystine knot peptides, derived from venom, have evolved to block ion channel function but are often toxic when dosed at pharmacol. relevant levels in vivo. The article describes the design of analogs of ProTx-II that safely display systemic in vivo blocking of Nav1.7, resulting in a latency of response to thermal stimuli in rodents. The new designs achieve a better in vivo profile by improving ion channel selectivity and limiting the ability of the peptides to cause mast cell degranulation. The design rationale, structural modeling, in vitro profiles, and rat tail flick outcomes are disclosed and discussed.

Product Details of C18H17NO5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., 73724-45-5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ackun-Farmmer, Marian A. team published research on FASEB Journal in 2021 | 73724-45-5

73724-45-5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., Quality Control of 73724-45-5

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Quality Control of 73724-45-5.

Ackun-Farmmer, Marian A.;Soto, Celia A.;Lesch, Maggie L.;Byun, Daniel;Yang, Lila;Calvi, Laura M.;Benoit, Danielle S. W.;Frisch, Benjamin J. research published 《 Reduction of leukemic burden via bone-targeted nanoparticle delivery of an inhibitor of C-chemokine (C-C motif) ligand 3 (CCL3) signaling》, the research content is summarized as follows. Leukemias are challenging diseases to treat due, in part, to interactions between leukemia cells and the bone marrow microenvironment (BMME) that contribute significantly to disease progression. Studies have shown that leukemic cells secrete C-chemokine (C-C motif) ligand 3 (CCL3), to disrupt the BMME resulting in loss of hematopoiesis and support of leukemic cell survival and proliferation. In this study, a murine model of blast crisis chronic myelogenous leukemia (bcCML) that expresses the translocation products BCR/ABL and Nup98/HoxA9 was used to determine the role of CCL3 in BMME regulation. Leukemic cells derived from CCL3-/- mice were shown to minimally engraft in a normal BMME, thereby demonstrating that CCL3 signaling was necessary to recapitulate bcCML disease. Further anal. showed disruption in hematopoiesis within the BMME in the bcCML model. To rescue the altered BMME, therapeutic inhibition of CCL3 signaling was investigated using bone-targeted nanoparticles (NP) to deliver Maraviroc, an inhibitor of C-C chemokine receptor type 5 (CCR5), a CCL3 receptor. NP-mediated Maraviroc delivery partially restored the BMME, significantly reduced leukemic burden, and improved survival. Overall, our results demonstrate that inhibiting CCL3 via CCR5 antagonism is a potential therapeutic approach to restore normal hematopoiesis as well as reduce leukemic burden within the BMME.

73724-45-5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., Quality Control of 73724-45-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Abdullaha, Mohd team published research on ACS Pharmacology & Translational Science in 2021 | 122775-35-3

Application In Synthesis of 122775-35-3, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., 122775-35-3.

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Application In Synthesis of 122775-35-3.

Abdullaha, Mohd;Ali, Mehboob;Kour, Dilpreet;Mudududdla, Ramesh;Khajuria, Parul;Kumar, Ajay;Bharate, Sandip B. research published 《 Tetramethoxystilbene Inhibits NLRP3 Inflammasome Assembly via Blocking the Oligomerization of Apoptosis-Associated Speck-like Protein Containing Caspase Recruitment Domain: In Vitro and In Vivo Evaluation》, the research content is summarized as follows. Nucleotide-binding domain leucine-rich repeat family pyrin domain containing 3 (NLRP3) inflammasome complex regulates the caspase-1 activity and subsequent processing of interleukin-1β (IL-1β). Various inflammatory diseases involve the activation of inflammasome complexes; thus, the intervention in complex formation via small mols. offers a new therapeutic opportunity. The structure-guided design and synthesis of a series of methoxystilbenes and methoxy-2-phenylnaphthalenes identified new inhibitors of NLRP3 inflammasome complex. The tetramethoxystilbene 4o and trimethoxy 2-phenylnaphthalene 1t inhibit the release of a mature form of IL-1β in J774A.1 cells with IC50 values of 1.39 and 2.07μM, resp. Mechanistic investigation revealed that tetramethoxystilbene 4o blocks the oligomerization of apoptosis-associated speck-like protein (ASC), which is the vital step in the formation of NLRP3 inflammasome assembly, thus preventing the activation of caspase-1 and the IL-1β release. Treatment of LPS+ATP challenged mice with 20 mg/kg of 4o significantly suppressed the levels of IL-1β. The data presented herein warrant further investigation of methoxystilbenes in disease-specific models of inflammatory diseases.

Application In Synthesis of 122775-35-3, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., 122775-35-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem