Month: September 2022

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Reference of 122775-35-3.

Das, Pritha;Das, Subhodeep;Jana, Ranjan research published 《 Aryldiazonium Salts and DABSO: A Versatile Combination for Three-Component Sulfonylative Cross-Coupling Reactions》, the research content is summarized as follows. A copper-catalyzed three-component cross-coupling of aryldiazonium salts, DABSO with arylboronic acids to obtain medicinally relevant unsym. diarylsulfones RSO₂R¹ [R = Ph, 4-FC₆H₄, 2-naphthyl, etc.; R¹ = 3-ClC₆H₄, 4-MeOC₆H₄, 2-SMeC₆H₄, etc.] was disclosed. Interestingly, a catalyst-free approach for the synthesis of arylvinylsulfones R²CH=CHSO₂R³ [R² = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, etc.; R³ = 4-MeC₆H₄, 3-ClC₆H₄, 4-MeOC₆H₄, 4-IC₆H_4, 3-CO₂MeC₆H₄] from the corresponding vinyl boronic acids or vinyl halides was explored under basic condition. Tethered aryldiazonium salts provided the corresponding annulated dihydrobenzofuran tethered alkylvinyl sulfones I [R⁴ = H, 5-Me, 5-Cl, 5-MeO; R⁵ = Ph, 4-MeC₆H₄, 4-FC₆H₄, 4-ClC₆H₄, 4-F₃CC₆H₄] via alkene difunctionalization under the same transition metal-free condition. Mechanistically, these multicomponent reactions proceeded through a single electron pathway by the formation of arylsulfonyl radical as a key intermediate.

Reference of 122775-35-3, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., 122775-35-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Application of C6H14O3.

Daryab, Mahshid;Faizi, Mehrdad;Mahboubi, Arash;Aboofazeli, Reza research published 《 Preparation and characterization of lidocaine-loaded, microemulsion-based topical gels》, the research content is summarized as follows. Microemulsion-based gels (MBGs) were prepared for transdermal delivery of lidocaine and evaluated for their potential for local anesthesia. Lidocaine solubility was measured in various oils, and phase diagrams were constructed to map the concentration range of oil, surfactant, cosurfactant, and water for oil-in-water (o/w) microemulsion (ME) domains, employing the water titration method at different surfactant/cosurfactant weight ratios. Refractive index, elec. conductivity, droplet size, zeta potential, pH, viscosity, and stability of fluid o/w MEs were evaluated. Carbomer 940 was incorporated into the fluid drug-loaded MEs as a gelling agent. Microemulsion-based gels were characterized for spreadability, pH, viscosity, and in-vitro drug release measurements, and based on the results obtained, the best MBGs were selected and subsequently subjected to ex-vivo rat skin permeation anesthetic effect and irritation studies. Data indicated the formation of nano-sized droplets of MEs ranging from 20-52 nm with a polydispersity of less than 0.5. In-vitro release and ex-vivo permeation studies on MBGs showed significantly higher drug release and permeation in comparison to the marketed topical gel. Developed MBG formulations demonstrated greater potential for transdermal delivery of lidocaine and advantage over the com. available gel product, and therefore, they may be considered as potential vehicles for the topical delivery of lidocaine.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Application of C6H14O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Product Details of C8H11BO4.

Darwish, Khaled M.;Abdelwaly, Ahmad;Atta, Asmaa M.;Helal, Mohamed A. research published 《 Discovery of tetrahydro-β-carboline- and indole-based derivatives as promising phosphodiesterase-4 inhibitors: Synthesis, biological evaluation, and molecular modeling studies》, the research content is summarized as follows. Phosphodiesterase-4 (PDE4) is responsible for the selective degradation of the 3′-cyclic phosphate bonds of cAMP. A collection of twenty-three diverse 1,2,3,4-tertahydro-β-carboline- and indole-based analogs were synthesized and assessed for their inhibitory activity against human PDE4. The compounds were prepared using straightforward procedures and characterized using ¹H- and ¹³C NMR, IR, and mass spectroscopy as well as elemental anal. Fifteen of the prepared compounds exhibited significant inhibitory activity with IC₅₀ values in the lower micromolar to upper nanomolar ranges. The most active compounds also showed good selectivity for PDE4 over the related enzyme family member, PDE5, with either insignificant or null% inhibition of the latter enzyme. The indole-based compounds, 21b (I) and 21c (II), showed the most pronounced PDE4 inhibition with IC₅₀ values of 754 and 664 nM, resp. The PDE4B active site comprises both hydrophobic and solvent-filled pockets. The hydrophobic pocket (Q) includes the invariant purine-selective Gln443 which is critical for cAMP. Below this Gln443 lies Phe446 which acts as a hydrophobic P-clamp stabilizing the ligand aromatic ring system. Mol. docking investigation showed preferential anchoring of the active compounds within the PDE4 active site through interactions between the indole nitrogens and the dimethoxy Ph groups with key residues. Overall, the prepared compounds are novel and simple mols. with good potential for future optimization. Showing satisfactory predicted ADME/safety and drug-likeness properties, compound 21c is considered a promising lead for further optimization towards clin. investigation against inflammatory, auto-immune diseases, or certain types of cancer.

Product Details of C8H11BO4, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., 122775-35-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 530-59-6, formula is C11H12O5, Name is 3,5-Dimethoxy-4-hydroxycinnamic acid. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Quality Control of 530-59-6.

Dar, Niyaz A.;Mir, Mudasir A.;Mir, Javid I.;Mansoor, Sheikh;Showkat, Wasia;Parihar, Tasmeen J.;Haq, Syed Anam Ul;Wani, Shabir H.;Zaffar, Gul;Masoodi, Khalid Z. research published 《 MYB-6 and LDOX-1 regulated accretion of anthocyanin response to cold stress in purple black carrot (Daucus carota L.)》, the research content is summarized as follows. Anthocyanin, an essential ingredient of functional foods, is present in a wide range of plants, including black carrots. The current investigation was carried out to analyze the effect of cold stress on the expression of major anthocyanins and anthocyanin biosynthetic pathway genes, MYB6 and LDOX-1. Methods and results: Five cultivated carrot genotypes belonging to the eastern group, having anthocyanin pigment, were used in the current study. The qRT-PCR anal. revealed that relative gene expression of transcription factor MYB-6 and LDOX1gene was highly expressed upon cold stress compared to non-stress samples. High-performance liquid chromatog.-based quantification of Cyanidin 3–glucoside (Kuromanin chloride), Ferulic acid, 3,5-Dimethoxy-4-hydroxycinnamic acid (Sinapic acid), and Rutin revealed a significant increase in these major anthocyanins in response to cold stress when compared to control plants. Conclusion: We conclude that MYB6 and LDOX1 gene expression increases upon cold stress, which induces accumulation of major anthocyanins in purple black carrot and suggests a possible cross-link between cold stress and anthocyanin biosynthesis in purple black carrot.

530-59-6, Sinapinic acid is a chemical compound that is the dihydroxybenzoic acid derivative of sinapic acid. It has been shown to have anti-inflammatory properties in vitro and in vivo. Sinapinic acid inhibits the activity of various enzymes, such as cyclooxygenase (COX), lipoxygenase (LOX), and 5-lipoxygenase-activating protein (FLAP). It also decreases levels of adhesion molecules and downregulates inflammatory response genes. Sinapinic acid has been shown to reduce inflammation by inhibiting the formation of proinflammatory mediators, such as prostaglandin E2 or leukotriene B4, in endothelial cells and mammary epithelial cells.
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities. Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM). It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively. Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold. It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively). In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil and bicuculline. Sinapic acid is also commonly used as a matrix in protein mass spectrometry.
Sinapic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.
Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.
cis-Sinapic acid, also known as cis-sinapate or synapitic acid, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated. cis-Sinapic acid is considered to be a practically insoluble (in water) and relatively neutral molecule. Within the cell, cis-sinapic acid is primarily located in the cytoplasm. Outside of the human body, cis-sinapic acid can be found in common pea and pulses. This makes cis-sinapic acid a potential biomarker for the consumption of these food products.
Cis-sinapic acid is a 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid in which the double bond has cis-configuration. It has been isolated from the shoots of alfalfa. It has a role as a plant metabolite., Quality Control of 530-59-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 530-59-6, formula is C11H12O5, Name is 3,5-Dimethoxy-4-hydroxycinnamic acid. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Safety of 3,5-Dimethoxy-4-hydroxycinnamic acid.

Danielski, Renan;Mazzutti, Simone;Ferreira, Sandra Regina Salvador;Vitali, Luciano;Block, Jane Mara research published 《 A non-conventional approach for obtaining phenolic antioxidants from red guava (Psidium guajava L.) by-products》, the research content is summarized as follows. The recovery of phenolic antioxidants from agro-industrial byproducts using non-conventional techniques is a powerful tool to explore the bioactive potential of natural sources. Therefore, it is imperative to analyze the most suitable method to investigate a plant material’s phenolic composition This study used ultra-turrax (UTE), ultrasonic bath (BUAE), and pressurized liquid (PLE) for soluble phenolic extraction from guava’s pulp and processing waste. UTE at 25°C for 1 h yielded the highest concentration of total phenolics and flavonoids from guava pulp, while PLE for 30 min at 60°C/10 MPa presented the best performance for flavonoids and condensed tannins recovery from guava waste. PLE produced extracts with 39 phenolics and high antioxidant capacity. Besides, scopoletin, resveratrol, and naringin are being reported for the first time in this fruit. These results suggest possible alternatives for the recovery of bioactive compound, which may be used to develop nutraceuticals and/or functional foods. Practical applications : Upon guava processing, 30% of fruit’s total volume is lost in the form of byproducts (seeds, peels, and pulp leftovers). Evidence points out that this fraction, along with guava’s pulp, is rich in phenolics with antioxidant properties. An extraction procedure should be conducted to recover these compounds However, conventional techniques are laborious, time-consuming, and they generally use a large amount of toxic organic solvent. Ultra-turrax-UTE, ultrasonic bath-BUAE, and pressurized liquid-PLE are non-conventional approaches that make possible the reduction of solvents and the recovery of selected phenolics not possible with conventional techniques. These extracts could be further applied to lipid-rich foods as a natural antioxidant system and/or as an ingredient in the development of nutraceuticals and functional foods.

Safety of 3,5-Dimethoxy-4-hydroxycinnamic acid, Sinapinic acid is a chemical compound that is the dihydroxybenzoic acid derivative of sinapic acid. It has been shown to have anti-inflammatory properties in vitro and in vivo. Sinapinic acid inhibits the activity of various enzymes, such as cyclooxygenase (COX), lipoxygenase (LOX), and 5-lipoxygenase-activating protein (FLAP). It also decreases levels of adhesion molecules and downregulates inflammatory response genes. Sinapinic acid has been shown to reduce inflammation by inhibiting the formation of proinflammatory mediators, such as prostaglandin E2 or leukotriene B4, in endothelial cells and mammary epithelial cells.
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities. Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM). It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively. Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold. It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively). In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil and bicuculline. Sinapic acid is also commonly used as a matrix in protein mass spectrometry.
Sinapic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.
Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.
cis-Sinapic acid, also known as cis-sinapate or synapitic acid, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated. cis-Sinapic acid is considered to be a practically insoluble (in water) and relatively neutral molecule. Within the cell, cis-sinapic acid is primarily located in the cytoplasm. Outside of the human body, cis-sinapic acid can be found in common pea and pulses. This makes cis-sinapic acid a potential biomarker for the consumption of these food products.
Cis-sinapic acid is a 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid in which the double bond has cis-configuration. It has been isolated from the shoots of alfalfa. It has a role as a plant metabolite., 530-59-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Application of C6H14O3.

Dangre, Pankaj V.;Gurram, Navya J.;Surana, Sanjay J.;Chalikwar, Shailesh S. research published 《 Development and Optimization of Vitamin D₃ Solid Self-Microemulsifying Drug Delivery System: Investigation of Flowability and Shelf Life》, the research content is summarized as follows. Abstract: We report herein the design of a solid self-microemulsifying drug delivery system (SMEDDS) of vitamin D3 for augmentation of its solubility and dissolution The studies employed a 32 full factorial design by employing JMP 13.2.1, software for preparation of liquid SMEDDS. Further, the prediction profiler was utilized to optimized liquid SMEDDS-Vit.D3 (OF) formulation. The solidification of liquid SMEDDS-Vit. D3 formulation was carried out by phys. adsorption over Neusilin US2 and Aerosil 200 carriers. Solid-state evaluation of SMEDDS-Vit. D3 suggested the transformation of crystalline to amorphous form of Vit. D3 which is responsible for imparting more aqueous solubility and thus enhancement in dissolution behavior. The investigation of flow behaviors viz. flow function (FF) and effective angle of wall friction (EAWF) of solid SMEDDS-Vit. D3 was performed using powder flow tester. Solid SMEDDS-Vit. D3 prepared using Neusilin US2 showed good flow behavior and hence was developed into tablets. The tablets showed good quality control parameters as per pharmacopeial standards The in vitro dissolution studies demonstrated more dissolution of Vit. D3 in SMEDDS (liquid, solid, and tablet) when compared to the unprocessed drug. The shelf life (T90) of tablets was reported to be 28.12 mo suggesting excellent stability of Vit.D3 in solid SMEDDS. In nutshell, our research works explore the utilization of SMEDDS for the oral delivery of Vit. D3 to gain maximum health-related benefits. Graphical abstract: [graphic not available: see fulltext].

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Application of C6H14O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 530-59-6, formula is C11H12O5, Name is 3,5-Dimethoxy-4-hydroxycinnamic acid. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Category: ethers-buliding-blocks.

da Silva, Elias Alves;Mendes, Thais Demarchi;Pacheco, Thalyta Fraga;Campanha, Raquel Bombarda;Wischral, Daiana;Mendonca, Simone;Camassola, Marli;de Siqueira, Felix Goncalves;Souza, Manoel Teixeira Junior research published 《 Colonization of oil palm empty fruit bunches by basidiomycetes from the Brazilian cerrado: deconstruction of biomass》, the research content is summarized as follows. This study aimed to establish a deconstruction process of oil palm empty fruit bunches (EFBs), employing hydrothermal and biol. pretreatments. Initially, the yields of cellulose, hemicellulose, lignin, extractives and ashes resulting from the autohydrolysis of raw EFBs were measured. The biol. pretreatment of the raw EFBs followed using eight basidiomycetes strains. Finally, an enzymic hydrolysis comparison between basidiomycetes and com. enzymes evaluated glucose and xylose yields, the synergism degree and the reduction of phenolic substances. Autohydrolysis pretreatment presented the best sugar yields after hydrolysis. However, biol. pretreatment provides enzymes and other advantages. The combination of enzymic extracts of basidiomycetes with Celluclast and Novozyme-188 Sigma gave the best glucose yield with Flavodon flavus BRM-055676 (14.78%). Synergism degree analyses showed an increase of 47% in glucose release by the cocktail of Fomes fasciatus BRM-055675 with com. enzymes. The deconstruction of EFBs by biol. pretreatment presented a 2.96 ratio loss of lignin/loss of cellulose with F. flavus BRM-055676. Finally, combinations of enzymic extracts from basidiomycetes and ascomycetes, mainly F. fasciatus BRM-055675, provided the reduction of phenolic substances. 2022 Society of Chem. Industry and John Wiley & Sons, Ltd.

Category: ethers-buliding-blocks, Sinapinic acid is a chemical compound that is the dihydroxybenzoic acid derivative of sinapic acid. It has been shown to have anti-inflammatory properties in vitro and in vivo. Sinapinic acid inhibits the activity of various enzymes, such as cyclooxygenase (COX), lipoxygenase (LOX), and 5-lipoxygenase-activating protein (FLAP). It also decreases levels of adhesion molecules and downregulates inflammatory response genes. Sinapinic acid has been shown to reduce inflammation by inhibiting the formation of proinflammatory mediators, such as prostaglandin E2 or leukotriene B4, in endothelial cells and mammary epithelial cells.
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities. Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM). It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively. Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold. It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively). In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil and bicuculline. Sinapic acid is also commonly used as a matrix in protein mass spectrometry.
Sinapic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.
Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.
cis-Sinapic acid, also known as cis-sinapate or synapitic acid, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated. cis-Sinapic acid is considered to be a practically insoluble (in water) and relatively neutral molecule. Within the cell, cis-sinapic acid is primarily located in the cytoplasm. Outside of the human body, cis-sinapic acid can be found in common pea and pulses. This makes cis-sinapic acid a potential biomarker for the consumption of these food products.
Cis-sinapic acid is a 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid in which the double bond has cis-configuration. It has been isolated from the shoots of alfalfa. It has a role as a plant metabolite., 530-59-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 530-59-6, formula is C11H12O5, Name is 3,5-Dimethoxy-4-hydroxycinnamic acid. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Quality Control of 530-59-6.

Da Costa, Maria Vera Jesus;Ramegowda, Venkategowda;Ramakrishnan, Padma;Nataraja, Karaba N.;Sheshshayee, M. Sreeman research published 《 Comparative metabolite profiling of rice contrasts reveal combined drought and heat stress signatures in flag leaf and spikelets》, the research content is summarized as follows. Under semi-irrigated ecosystem, rice is often exposed to a combination of drought and heat stress, especially at the reproductive stage, leading to substantial yield loss. Combined stress studies are very limited in rice partly due to the difficulty in creating heat stress on a larger scale. Here, 24 cultivars with specific stress adaptive traits were phenotyped for spikelet sterility under combined stress using the natural summer temperatures and open drought phenotyping facility, simulating the field conditions. LC-MS/MS based metabolite profiling was performed in flag leaves and spikelets of three cultivars contrasting for spikelet sterility and source (leaf weight) treated to drought, heat and combined stress. Constitutively regulated metabolites, metabolic signatures common to all stresses, cultivars and tissues, metabolites common to both the tissues across the stresses and cultivars and metabolites common to each cultivar across the tissues and stresses were identified. Under combined stress, metabolites differentially accumulated between cultivars contrasting for spikelet sterility but similar for source and cultivars contrasting for both spikelet sterility and source have been identified. These metabolites would serve as markers towards improving combined stress tolerance of rice.

Quality Control of 530-59-6, Sinapinic acid is a chemical compound that is the dihydroxybenzoic acid derivative of sinapic acid. It has been shown to have anti-inflammatory properties in vitro and in vivo. Sinapinic acid inhibits the activity of various enzymes, such as cyclooxygenase (COX), lipoxygenase (LOX), and 5-lipoxygenase-activating protein (FLAP). It also decreases levels of adhesion molecules and downregulates inflammatory response genes. Sinapinic acid has been shown to reduce inflammation by inhibiting the formation of proinflammatory mediators, such as prostaglandin E2 or leukotriene B4, in endothelial cells and mammary epithelial cells.
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities. Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM). It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively. Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold. It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively). In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil and bicuculline. Sinapic acid is also commonly used as a matrix in protein mass spectrometry.
Sinapic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.
Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.
cis-Sinapic acid, also known as cis-sinapate or synapitic acid, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated. cis-Sinapic acid is considered to be a practically insoluble (in water) and relatively neutral molecule. Within the cell, cis-sinapic acid is primarily located in the cytoplasm. Outside of the human body, cis-sinapic acid can be found in common pea and pulses. This makes cis-sinapic acid a potential biomarker for the consumption of these food products.
Cis-sinapic acid is a 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid in which the double bond has cis-configuration. It has been isolated from the shoots of alfalfa. It has a role as a plant metabolite., 530-59-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 530-59-6, formula is C11H12O5, Name is 3,5-Dimethoxy-4-hydroxycinnamic acid. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Application of C11H12O5.

Czubinski, Jaroslaw;Dwiecki, Krzysztof research published 《 Molecular structure-affinity relationship of selected phenolic compounds for lupin seed γ-conglutin》, the research content is summarized as follows. The mol. basis underlying the interaction between proteins and phenolic compounds are still not fully understood. The specific structural properties of proteins, as well as phenolics, strongly determine the complex formation. In this work, the interactions between γ -conglutin, a unique lupin seed protein, and twenty-one different phenolic compounds representing six different classes of phenolics that differ in their structures were investigated. The interactions were studied based on a fluorescence quenching experiment, and the determined binding constant (Ka) ranged from 6.88 x 10² (protocatechuic acid) to 5.06 x 106 (hesperidin), while the number of binding sites of phenolic compound mols. to the protein (n) was on average 1.14 ± 0.16. Within the analyzed compounds, phenolic acids interacted the weakest with the protein, while flavonoids showed considerable higher affinity strength to γ-conglutin. Notably, flavanones and flavones were the phenolics that formed the complex with markedly higher values of Ka (1-3 orders of magnitude) and n. Addnl., principal component anal. allowed to formulate the general regularities of phenolic compounds preferences for γ-conglutin. Finally, the obtained results also indicate that phenolic compounds’ binding preferences for γ-conglutin can result from their native occurrence in lupin seeds.

Application of C11H12O5, Sinapinic acid is a chemical compound that is the dihydroxybenzoic acid derivative of sinapic acid. It has been shown to have anti-inflammatory properties in vitro and in vivo. Sinapinic acid inhibits the activity of various enzymes, such as cyclooxygenase (COX), lipoxygenase (LOX), and 5-lipoxygenase-activating protein (FLAP). It also decreases levels of adhesion molecules and downregulates inflammatory response genes. Sinapinic acid has been shown to reduce inflammation by inhibiting the formation of proinflammatory mediators, such as prostaglandin E2 or leukotriene B4, in endothelial cells and mammary epithelial cells.
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities. Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM). It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively. Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold. It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively). In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil and bicuculline. Sinapic acid is also commonly used as a matrix in protein mass spectrometry.
Sinapic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.
Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.
cis-Sinapic acid, also known as cis-sinapate or synapitic acid, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated. cis-Sinapic acid is considered to be a practically insoluble (in water) and relatively neutral molecule. Within the cell, cis-sinapic acid is primarily located in the cytoplasm. Outside of the human body, cis-sinapic acid can be found in common pea and pulses. This makes cis-sinapic acid a potential biomarker for the consumption of these food products.
Cis-sinapic acid is a 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid in which the double bond has cis-configuration. It has been isolated from the shoots of alfalfa. It has a role as a plant metabolite., 530-59-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem