Safety of DimethoxydiphenylmethaneIn 2017, Wu, Zhiyong;Leboeuf, David;Retailleau, Pascal;Gandon, Vincent;Marinetti, Angela;Voituriez, Arnaud published 《Enantioselective gold(I)-catalyzed rearrangement of cyclopropyl-substituted 1,6-enynes into 2-oxocyclobutyl-cyclopentanes》. 《Chemical Communications (Cambridge, United Kingdom)》published the findings. The article contains the following contents:
A gold(I)-catalyzed cycloisomerization/ring expansion sequence allows the highly enantioselective synthesis of 2-oxocyclobutylcyclopentane derivatives from cyclopropyl-substituted enynes [e.g., I → cis-II + trans-III (87%, cis/trans = 4.9/1, 99% ee cis) when conducted in wet toluene]. The bimetallic [(R)-MeO-DTBM-BIPHEP-(AuCl)2] complex was found to be the best precatalyst, affording the desired cyclobutanones in high yields and enantioselectivities (up to 99% ee). The usefulness of the method was further demonstrated by preparing the tricyclic core scaffold of russujaponol D (IV). And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.
For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Safety of Dimethoxydiphenylmethane
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem