Sorlin, Alexandre M.;Mixdorf, Jason C.;Rotella, Madeline E.;Martin, Robert T.;Gutierrez, Osvaldo;Nguyen, Hien M. published 《The Role of Trichloroacetimidate To Enable Iridium-Catalyzed Regio- and Enantioselective Allylic Fluorination: A Combined Experimental and Computational Study》 in 2019. The article was appeared in 《Journal of the American Chemical Society》. They have made some progress in their research.Related Products of 2235-01-0 The article mentions the following:
Asym. allylic fluorination has proven to be a robust and efficient methodol. with potential applications for the development of pharmaceuticals and practical synthesis for 18F-radiolabeling. A combined computational (dispersion-corrected DFT) and exptl. approach was taken to interrogate the mechanism of the diene-ligated, iridium-catalyzed regio- and enantioselective allylic fluorination. Our group has shown that, in the presence of an iridium(I) catalyst and nucleophilic fluoride source (Et3N·3HF), allylic trichloroacetimidates undergo rapid fluoride substitution to generate allylic fluoride products with excellent levels of branched-to-linear ratios. Mechanistic studies reveal the crucial role of the trichloroacetimidate as a potent leaving group and ligand to enable conversion of racemic allylic trichloroacetimidates to the corresponding enantioenriched allylic fluorides, via a dynamic kinetic asym. transformation (DYKAT), in the presence of the chiral bicyclo[3.3.0]octadiene-ligated iridium catalyst. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.
The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Related Products of 2235-01-0
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem