Koellmann, Christoph;Sake, Svenja M.;Jones, Peter G.;Pietschmann, Thomas;Werz, Daniel B. published 《Protecting-Group-Mediated Diastereoselective Synthesis of C4′-Methylated Uridine Analogs and Their Activity against the Human Respiratory Syncytial Virus》. The research results were published in《Journal of Organic Chemistry》 in 2020.Recommanded Product: 2235-01-0 The article conveys some information:
Adjusting the protecting group strategy, from an alkyl ether to a bidentate ketal at the carbohydrate backbone of uridine, facilitates a switchable diastereoselective α- or β-C4‘/C5‘-spiro-cyclopropanation. Using these spiro-cyclopropanated nucleosides as key intermediates, we synthesized a variety of C4‘-methylated D-ribose and L-lyxose configured uridine derivatives by a base-mediated ring-opening of the spiro-cyclopropanol moiety. Investigations of antiviral activity against HRSV were carried out for selected derivatives, showing moderate activity. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.
For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Recommanded Product: 2235-01-0
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem