Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Product Details of C6H14O3.
Hussain, Afzal;Alshehri, Sultan;Ramzan, Mohhammad;Afzal, Obaid;Altamimi, Abdulmalik S. A.;Alossaimi, Manal A. research published 《 Biocompatible solvent selection based on thermodynamic and computational solubility models, in-silico GastroPlus prediction, and cellular studies of ketoconazole for subcutaneous delivery》, the research content is summarized as follows. We aimed to identify a suitable solvent [dimethyl acetamide (DMA), Et acetate, (EA), N-Me pyrrolidone (NMP), cremophor-EL (CEL), transcutol-HP (THP), polyethylene glycol 400 (PEG-400), limonene and ethanol] based on exptl. solubility, thermodn./computational parameters for s.c. (sub-Q) delivery. The “van′t Hoff” model validated solubility values in several solvents at “T = 298.2 K-318.2 K” and “p = 0.1 MPa”. In silico prediction study was carried out for sub-Q delivery using GastroPlus. The selected KETO-DMA construct was evaluated for cellular interaction, cellular uptake (L929 cells), cytotoxicity (L929 and J774A.1) and antifungal activities (C. albicans, C. glabrata, C. Tropicalis, and A. niger). The maximum mole fractional solubility of KETO were found in three solvents such as DMA (4.8 x 10-2) EA (2.8 x 10-2) NMP (11.7 x 10-3) at “T = 318.2 K”. Anal. confirmed “endothermic and entropy” driven solubilization process. GastroPlus predicted pharmacokinetics parameters were influenced with nonsaturable metabolic clearance in s.c. tissue of human. Interaction study of KETO-DMA solution with Candida cells showed maximized cellular internalization. KETO-DMA solution exhibited poor cellular uptake by L929 cell lines (murine fibroblast cells) compared to KETO aqueous solution which was further supported with cytotoxicity study in L929 and J774A.1 cell lines. Reduced MIC values of KETO-DMA solution as compared to KETO aqueous solution against four strains corroborated improved efficacy of KETO probably due to augmented solubility in DMA and lack of surfactant. Thus, KETO-DMA solution can be a suitable construct for sub-Q delivery to control fungal infections.
Product Details of C6H14O3, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem