Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Safety of Diethylene Glycol Monoethyl Ether.
Hassan, Ahmad;Sahni, Jasjeet Kaur;Ali, Javed research published 《 Development and evaluation of oral nanoemulsion for the bioavailability enhancement of telmisartan》, the research content is summarized as follows. The present study aimed at developing an optimal oral nanoemulsion of telmisartan and evaluating its stability, pharmacodynamic and pharmacokinetic potential. Solubility of telmisartan was determined in various oils, surfactants & cosurfactants. Formulations were selected from the o/w nanoemulsion region from the help of pseudoternary phase diagrams and were subjected to various thermodn. stability and dispersibility tests. Optimized formulations were characterized for their percentage transmittance, refractive index, viscosity, droplet size and zeta potential & TEM. Release rate of optimized formulations was determined using an in vitro dissolution test. The formulation used for lowering of induced hypertension contained Soyabean oil (10%, volume/volume), Tween 20 (22.50%, volume/volume), Transcutol HP (7.5%, volume/volume) & double distilled water (60% volume/volume). The release of drug from the nanoemulsion formulations was highly significant (p < 0.01) in comparison to the drug suspension. More than 40% of the drug was released in the initial 1 h of the dissolution study in comparison to the drug suspension. The lowering of blood pressure in the group administered with the formulation F2 was highly significant (p < 0.01) with respect to the group administered with the marketed formulation. The plasma concentration time profile of telmisartan from oral nanoemulsion represented greater improvement of drug absorption than the marketed formulation. The shelf life of the nanoemulsion was found to be 1.5 years at room temperature The present study established oral nanoemulsion formulation to be one of the possible alternatives to traditional oral formulations of telmisartan to improve its bioavailability.
Safety of Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem