Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Application In Synthesis of 111-90-0.
Haq, Nazrul;Alghaith, Adel F.;Alshehri, Sultan;Shakeel, Faiyaz research published 《 Solubility and Thermodynamic Data of Febuxostat in Various Mono Solvents at Different Temperatures》, the research content is summarized as follows. This study examines the solubility and thermodn. of febuxostat (FBX) in a variety of mono solvents, including “water, methanol (MeOH), ethanol (EtOH), isopropanol (IPA), 1-butanol (1-BuOH), 2-butanol (2-BuOH), ethylene glycol (EG), propylene glycol (PG), polyethylene glycol-400 (PEG-400), Et acetate (EA), Transcutol-HP (THP), and DMSO (DMSO)” at 298.2-318.2 K and 101.1 kPa. The solubility of FBX was determined using a shake flask method and correlated with “van’t Hoff, Buchowski-Ksiazczak λh, and Apelblat models”. The overall error values for van’t Hoff, Buchowski-Ksiazczak λh, and Apelblat models was recorded to be 1.60, 2.86, and 1.14%, resp. The maximum mole fraction solubility of FBX was 3.06 × 10-2 in PEG-400 at 318.2 K, however the least one was 1.97 × 10-7 in water at 298.2 K. The FBX solubility increased with temperature and the order followed in different mono solvents was PEG-400 (3.06 × 10-2) > THP (1.70 × 10-2) > 2-BuOH (1.38 × 10-2) > 1-BuOH (1.37 × 10-2) > IPA (1.10 × 10-2) > EtOH (8.37 × 10-3) > EA (8.31 × 10-3) > DMSO (7.35 × 10-3) > MeOH (3.26 × 10-3) > PG (1.88 × 10-3) > EG (1.31 × 10-3) > water (1.14 × 10-6) at 318.2 K. Compared to the other combinations of FBX and mono solvents, FBX-PEG-400 had the strongest solute-solvent interactions. The apparent thermodn. anal. revealed that FBX dissolution was “endothermic and entropy-driven” in all mono solvents investigated. Based on these findings, PEG-400 appears to be the optimal co-solvent for FBX solubility
111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Application In Synthesis of 111-90-0
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem