Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Quality Control of 122775-35-3.
Egharevba, Godshelp O.;Kamal, Ahmed;Dosumu, Omotayo O.;Routhu, Sunitha;Fadare, Olatomide A.;Oguntoye, Stephen O.;Njinga, Stanislaus N.;Oluyori, Abimbola P. research published 《 Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies》, the research content is summarized as follows. Novel 1,1-diaryl vinyl-sulfones I [R = Ph, 4-MeOC6H4, 2,4-di-FC6H3, etc.] analogs of combretastatin CA-4 were synthesized via Suzuki-Miyaura coupling method and screened for in-vitro antiproliferative activity against four human cancer cell lines: MDA-MB 231(breast cancer), HeLa (cervical cancer), A549 (lung cancer), and IMR-32 (neuroblast cancer), along with a normal cell line HEK-293 (human embryonic kidney cell) by employing 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. The compounds synthesized had better cytotoxicity against the A549 and IMR-32 cell lines compared to HeLa and MDA-MB-231 cell lines. The synthesized compounds also showed significant activity on MDA-MB-231 cancer cell line with IC50 of 9.85-23.94μM, and on HeLa cancer cell line with IC50 of 8.39-11.70μM relative to doxorubicin having IC50 values 0.89 and 1.68μM resp. for MDA-MB-231 and HeLa cell lines. All the synthesized compounds were not toxic to the growth of normal cells, HEK-293. They appeared to have a higher binding affinity for the target protein, tubulin, PDB ID = 5LYJ (beta chain), relative to the reference compounds, CA4 (- 7.1 kcal/mol) and doxorubicin (- 7.2 kcal/mol) except for I [R = 3,5-di-MeOC6H3, 4-ClC6H4, 3,4-di-ClC6H3, 4-NCC6H4]. The high binding affinity for beta-tubulin was not translated into enhanced cytotoxicity but the compounds I [R = 4-FC6H4, 2,4-di-FC6H3, 3,4-di-FC6H3, 4-ClC6H4, 3,4-di-ClC6H3, 2-F-5-Me-C6H3] that had a higher cell permeability (as predicted in-silico) demonstrated an optimum cytotoxicity against the tested cell lines in an almost uniform manner for all tested cell lines. The in-silico study provided insight into the role that cell permeability plays in enhancing the cytotoxicity of this class of compounds and as potential antiproliferative agents.
Quality Control of 122775-35-3, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., 122775-35-3.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem