Franchini, Silvia;Sorbi, Claudia;Linciano, Pasquale;Carnevale, Gianluca;Tait, Annalisa;Ronsisvalle, Simone;Buccioni, Michela;Del Bello, Fabio;Cilia, Antonio;Pirona, Lorenza;Denora, Nunzio;Iacobazzi, Rosa Maria;Brasili, Livio published 《1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity》. The research results were published in《European Journal of Medicinal Chemistry》 in 2019.Application of 2235-01-0 The article conveys some information:
A series of compounds generated by ring expansion/opening and mol. elongation/simplification of the 1,3-dioxolane scaffold were prepared and tested for binding affinity at 5-HT1AR and α1 adrenoceptors. The compounds with greater affinity were selected for further functional studies. N-((2,2-diphenyl-1,3-dioxan-5-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-ammonium hydrogen oxalate I emerged as highly potent full agonist at the 5-HT1AR (pKi 5-HT1A = 8.8; pD2 = 9.22, %Emax = 92). The pharmacokinetic data in rats showed that the orally administered I has a high biodistribution in the brain compartment. Thus, I was further investigated in-vivo, showing an anxiolytic and antidepressant effect. Moreover, in the formalin test, the above compound was able to decrease the late response to the noxious stimulus, indicating a potential use in the treatment of chronic pain. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.
The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Application of 2235-01-0
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem