Application of cas: 2235-01-0 | Utech, Tina et al. published an article in 2011

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Application of 2235-01-0

Utech, Tina;Koehler, Jens;Wuensch, Bernhard published 《Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists》 in 2011. The article was appeared in 《European Journal of Medicinal Chemistry》. They have made some progress in their research.Application of 2235-01-0 The article mentions the following:

Elongation of the distance between the oxygen heterocycle and the basic amino moiety or ring expansion of the oxygen heterocycle of the NMDA receptor antagonists dexoxadrol and etoxadrol led to compounds with promising NMDA receptor affinity. Herein the combination of both structural features, i.e. elongation of the O-heterocycle – amine distance with a 1,3-dioxane ring is envisaged. The synthesis of aminoethyl-1,3-dioxanes was performed by transacetalization of various acetals with pentane-1,3,5-triol, activation of the remaining free OH moiety with tosyl chloride and subsequent nucleophilic substitution. The corresponding 3-aminopropyl derivatives were prepared by substitution of the tosylates with KCN and LiAlH4 reduction The highest NMDA receptor affinity was found for 4-(2-aminoethyl)-2-ethyl-2-phenyl-1,3-dioxane (I) followed by 2,2-diphenyl- and 2-Ph analogs.. Generally the NMDA affinity of primary amines is higher than the NMDA affinity of secondary and tertiary amines. Altogether I (Ki = 24 nM) represents the most promising NMDA receptor antagonist of this series exceeding the NMDA affinity of (2-aminoethyl)-1,3-dioxolanes and (2-aminomethyl)-1,3-dioxanes. Whereas I turned out to be selective against σ1 and σ2 receptors 4-(2-benzylaminoethyl)-2-phenyl-1,3-dioxane was identified as potent (Ki = 19 nM) and selective σ1 antagonist, which showed extraordinarily high antiallodynic activity in the capsaicin assay. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Application of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem