Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Application of C6H14O3.
Dangre, Pankaj V.;Gurram, Navya J.;Surana, Sanjay J.;Chalikwar, Shailesh S. research published 《 Development and Optimization of Vitamin D3 Solid Self-Microemulsifying Drug Delivery System: Investigation of Flowability and Shelf Life》, the research content is summarized as follows. Abstract: We report herein the design of a solid self-microemulsifying drug delivery system (SMEDDS) of vitamin D3 for augmentation of its solubility and dissolution The studies employed a 32 full factorial design by employing JMP 13.2.1, software for preparation of liquid SMEDDS. Further, the prediction profiler was utilized to optimized liquid SMEDDS-Vit.D3 (OF) formulation. The solidification of liquid SMEDDS-Vit. D3 formulation was carried out by phys. adsorption over Neusilin US2 and Aerosil 200 carriers. Solid-state evaluation of SMEDDS-Vit. D3 suggested the transformation of crystalline to amorphous form of Vit. D3 which is responsible for imparting more aqueous solubility and thus enhancement in dissolution behavior. The investigation of flow behaviors viz. flow function (FF) and effective angle of wall friction (EAWF) of solid SMEDDS-Vit. D3 was performed using powder flow tester. Solid SMEDDS-Vit. D3 prepared using Neusilin US2 showed good flow behavior and hence was developed into tablets. The tablets showed good quality control parameters as per pharmacopeial standards The in vitro dissolution studies demonstrated more dissolution of Vit. D3 in SMEDDS (liquid, solid, and tablet) when compared to the unprocessed drug. The shelf life (T90) of tablets was reported to be 28.12 mo suggesting excellent stability of Vit.D3 in solid SMEDDS. In nutshell, our research works explore the utilization of SMEDDS for the oral delivery of Vit. D3 to gain maximum health-related benefits. Graphical abstract: [graphic not available: see fulltext].
111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Application of C6H14O3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem