Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Application In Synthesis of 111-90-0.
Choi, Hoo-kyun;Acharya, Gayathri;Lee, Yugyung;Lee, Chi H. research published 《 A Data-Mining Approach for the Quantitative Assessment of Physicochemical Properties of Molecular Compounds in the Skin Flux》, the research content is summarized as follows. This paper aimed to provide an insight into the mechanism of transdermal penetration of drug mols. with respect to their physicochem. properties, such as solubility (S), the presence of enantiomer (ET) and logarithm of octanol-water partition coefficient (log P), mol. weight (MW), and m.p. (MP). Propionic acid derivatives were evaluated for their flux through full-thickness skin excised from hairless mice upon being delivered from silicone-based pressure-sensitive adhesive (PSA) matrixes in the presence or absence of various enhancers. The skin fluxes of model compounds were calculated based on the data obtained using the method engaged with the diffusion cell system. The statistical design of experiments (DoE) based on the factorial approach was used to find variables that have a significant impact on the outcomes. For the prediction of skin flux, a quant. equation was derived using the data-mining approach on the relationship between skin permeation of model compounds (∼125 mg/mL) and involved physicochem. variables. The most influential variables for the skin flux of propionic acid derivatives were the m.p. (0.97) followed by the presence of enantiomer (0.95), mol. mass (0.93), log P values (0.86), and aqueous solubility (0.80). It was concluded that the skin flux of mol. compounds can be predicted based on the relationship between their physicochem. properties and the interaction with cofactors including additives and enhancers in the vehicles.
111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Application In Synthesis of 111-90-0
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem