Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Recommanded Product: Diethylene Glycol Monoethyl Ether.
Anwer, Khalid Md;Iqbal, Muzaffar;Aldawsari, Mohammed F.;Alalaiwe, Ahmed;Ahmed, Mohammed Muqtader;Muharram, Magdy M.;Ezzeldin, Essam;Mahmoud, Mohamed A.;Imam, Faisal;Ali, Raisuddin research published 《 Improved antimicrobial activity and oral bioavailability of delafloxacin by self-nanoemulsifying drug delivery system (SNEDDS)》, the research content is summarized as follows. In the current study, a novel self-nanoemulsifying drug delivery system (SNEDDS) was developed in order to improve the oral bioavailability of delafloxacin (DLF). Various oils, surfactants and co-surfactants were screened by solubility studies. Based on solubilization, potential of DLF in various vehicles, Lauroglycol-90 (oil), Tween 80 (surfactant) and Transcutol-HP (co-surfactant) were selected for the development of DLF loaded SNEDDS (DLF-SNEDDS). Four formulas of DLF loaded SNEDDS (DLF1-DLF4) were prepared and evaluated for their droplet size, polydispersity index (PDI), zeta potential (ZP), refractive index (RI), percent transmittance (%T), thermodn. stability, emulsifying efficiency and in vitro release studies. Among developed DLF loaded SNEDDS (DLF1-DLF4), DLFI was found optimum with a droplet size (73.3 ± 6.5 nm) PDI (0.298) ZP (-22.3) RI (1.334 ± 0.05) and %T (99.2 ± 0.09). Optimized DLF loaded SNEDDS (DLF1) demonstrated a superior anti-microbial activity against tested gram pos. and gram neg. strains with no resistance. The pharmacokinetic studies showed that oral bioavailability of DLF was significantly improved (3- fold) by optimized DLF loaded SNEDDS (DLF1) in comparison to pure DLF suspension. Hence, the results of this work suggest that the developed SNEDDS could be a potential carrier in enhancing bioavailability and therapeutic efficacy of DLF.
Recommanded Product: Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem