Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Synthetic Route of 73724-45-5.
Braga Emidio, Nayara;Meli, Rajeshwari;Tran, Hue N. T.;Baik, Hayeon;Morisset-Lopez, Severine;Elliott, Alysha G.;Blaskovich, Mark A. T.;Spiller, Sabrina;Beck-Sickinger, Annette G.;Schroeder, Christina I.;Muttenthaler, Markus research published 《 Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite》, the research content is summarized as follows. TFF3 regulates essential gastro- and neuroprotective functions, but its mol. mode of action remains poorly understood. Synthetic intractability and lack of reliable bioassays and validated receptors are bottlenecks for mechanistic and structure-activity relationship studies. Here, we report the chem. synthesis of TFF3 and its homodimer via native chem. ligation followed by oxidative folding. Correct folding was confirmed by NMR and CD, and TFF3 and its homodimer were not cytotoxic or hemolytic. TFF3, its homodimer, and the trefoil domain (TFF310-50) were susceptible to gastrointestinal degradation, revealing a gut-stable metabolite (TFF37-54; t1/2 > 24 h) that retained its trefoil structure and antiapoptotic bioactivity. We tried to validate the putative TFF3 receptors CXCR4 and LINGO2, but neither TFF3 nor its homodimer displayed any activity up to 10μM. The discovery of a gut-stable bioactive metabolite and reliable synthetic accessibility to TFF3 and its analogs are cornerstones for future mol. probe development and structure-activity relationship studies.
73724-45-5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., Synthetic Route of 73724-45-5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem