Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Safety of Fmoc-Ser-OH.
Bhaumik, Kaushik Nath;Hetenyi, Anasztazia;Olajos, Gabor;Martins, Ana;Spohn, Reka;Nemeth, Lukacs;Jojart, Balazs;Szili, Petra;Dunai, Anett;Jangir, Pramod K.;Daruka, Lejla;Foldesi, Imre;Kata, Diana;Pal, Csaba;Martinek, Tamas A. research published 《 Rationally designed foldameric adjuvants enhance antibiotic efficacy via promoting membrane hyperpolarization》, the research content is summarized as follows. The neg. membrane potential of bacterial cells influences crucial cellular processes. Inspired by the mol. scaffold of the antimicrobial peptide PGLa, we have developed antimicrobial foldamers with a computer-guided design strategy. The novel PGLa analogs induce sustained membrane hyperpolarization. When co-administered as an adjuvant, the resulting compounds – PGLb1 and PGLb2 – have substantially reduced the level of antibiotic resistance of multi-drug resistant Escherichia coli, Klebsiella pneumoniae and Shigella flexneri clin. isolates. The observed antibiotic potentiation was mediated by hyperpolarization of the bacterial membrane caused by the alteration of cellular ion transport. Specifically, PGLb1 and PGLb2 are selective ionophores that enhance the Goldman-Hodgkin-Katz potential across the bacterial membrane. These findings indicate that manipulating bacterial membrane electrophysiol. could be a valuable tool to overcome antimicrobial resistance.
Safety of Fmoc-Ser-OH, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., 73724-45-5.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem