Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Application In Synthesis of 38256-93-8.
Baranczak, Aleksandra;Tu, Noah P.;Marjanovic, Jasmina;Searle, Philip A.;Vasudevan, Anil;Djuric, Stevan W. research published 《 Integrated Platform for Expedited Synthesis-Purification-Testing of Small Molecule Libraries》, the research content is summarized as follows. The productivity of medicinal chem. programs can be significantly increased through the introduction of automation, leading to shortened discovery cycle times. Herein, the authors describe a platform that consolidates synthesis, purification, quantitation, dissolution, and testing of small mol. libraries. The system was validated through the synthesis and testing of two libraries of binders of polycomb protein EED, and excellent correlation of obtained data with results generated through conventional approaches was observed The fully automated and integrated platform enables batch-supported compound synthesis based on a broad array of chem. transformations with testing in a variety of biochem. assay formats. A library turnaround time of between 24 and 36 h was achieved, and notably, each library synthesis produces sufficient amounts of compounds for further evaluation in secondary assays thereby contributing significantly to the shortening of medicinal chem. discovery cycles.
Application In Synthesis of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem