Synthetic Route of C15H16O2《Improved Benson Increments for the Estimation of Standard Enthalpies of Formation and Enthalpies of Vaporization of Alkyl Ethers, Acetals, Ketals, and Ortho Esters》 was published in 2002. The authors were Verevkin, Sergey P., and the article was included in《Journal of Chemical and Engineering Data》. The author mentioned the following in the article:
This work was undertaken for the evaluation and revision of group-additivity values necessary for predicting standard enthalpies of formation and enthalpies of vaporization of ethers, acetals, ketals, and ortho esters by means of Benson’s group-additivity methodol. The database on the standard molar enthalpies of vaporization ΔlgHm0 has been extended with measurements on several acetals, ketals, and ortho esters using the transpiration method. The standard molar enthalpies of formation ΔfHm0 (g, 298.15K) of alkyl ethers, acetals, ketals, and ortho esters were derived using the data for the ΔfHm0(l or cr, 298.15K) from the literature and the present results for the enthalpies of vaporization or sublimation. The current database of exptl. data for enthalpies of formation and enthalpies of vaporization at 298.15 K have been used to reevaluate the values of the Benson’s increments for of alkyl ethers, acetals, ketals, and ortho esters. The group-additivity parameters and strain corrections useful in the application of the Benson’s correlation are presented in tabular form, together with a description of their evaluation. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .
The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Synthetic Route of C15H16O2
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem