Zhang, Shuai;Perveen, Saima;Ouyang, Yizhao;Xu, Liang;Yu, Tao;Zhao, Min;Wang, Linghua;Song, Peidong;Li, Pengfei published 《Design and Synthesis of Tunable Chiral 2,2′-Bipyridine Ligands: Application to the Enantioselective Nickel-Catalyzed Reductive Arylation of Aldehydes》 in 2022. The article was appeared in 《Angewandte Chemie, International Edition》. They have made some progress in their research.Safety of Dimethoxydiphenylmethane The article mentions the following:
A new class of chiral 2,2′-bipyridine ligands, SBpy, featuring minimized short-range steric hindrance and structural tunability was rationally designed and developed, and the effectiveness was demonstrated in the first highly enantioselective Ni-catalyzed addition of aryl halides to aldehydes. In comparison with known approaches using preformed aryl metallic reagents, this reaction is more step-economical and functional group tolerant. The reaction mechanism and a model of stereocontrol were proposed based on exptl. and computational results. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .
Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Safety of Dimethoxydiphenylmethane The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem