Reference of DimethoxydiphenylmethaneIn 2007, Dei, Silvia;Bellucci, Cristina;Buccioni, Michela;Ferraroni, Marta;Guandalini, Luca;Manetti, Dina;Martini, Elisabetta;Marucci, Gabriella;Matucci, Rosanna;Nesi, Marta;Romanelli, Maria Novella;Scapecchi, Serena;Teodori, Elisabetta published 《Synthesis, Affinity Profile, and Functional Activity of Muscarinic Antagonists with a 1-Methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine Structure》. 《Journal of Medicinal Chemistry》published the findings. The article contains the following contents:
Starting from a previously studied muscarinic ligand, characterized by a 1,3-oxathiolane nucleus, a series of muscarinic antagonists were designed by increasing the stereochem. complexity of the mols. A small library of enantiomeric and diastereomeric 2,2-diphenyl- and 2-cyclohexyl-2-Ph substituted compounds, e.g., I, was thus obtained. All the tested compounds show a high affinity toward cloned human muscarinic hm1-hm5 receptors expressed in CHO cells and a good antagonistic activity on functional assays, with a modest selectivity on rabbit vas deferens. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .
Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Reference of Dimethoxydiphenylmethane The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem