Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 56621-48-8, is researched, SMILESS is OC1=CC=C(N2CCNCC2)C=C1, Molecular C10H14N2OJournal, Article, Research Support, Non-U.S. Gov’t, Bioorganic & Medicinal Chemistry called Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors, Author is Neves, Gilda; Menegatti, Ricardo; Antonio, Camila B.; Grazziottin, Luiza R.; Vieira, Renan O.; Rates, Stela M. K.; Noel, Francois; Barreiro, Eliezer J.; Fraga, Carlos A. M., the main research direction is heterocyclic phenylpiperazine preparation D2 HT1A receptor ligand antipsychotic.Recommanded Product: 4-(Piperazin-1-yl)phenol.
The authors described herein the design, synthesis, and pharmacol. evaluation of N-phenylpiperazine heterocyclic derivatives as multi-target compounds potentially useful for the treatment of schizophrenia. The isosteric replacement of the heterocyclic ring at the biaryl motif generating pyrazole, 1,2,3-triazole, and 2-methylimidazole[1,2-a]pyridine derivatives resulted in 21 analogs with different substitutions at the para-biaryl and para-phenylpiperazine positions. Among the compounds prepared, 4 (LASSBio-579) and 10 (LASSBio-664) exhibited an adequate binding profile and a potential for schizophrenia pos. symptoms treatment without cataleptogenic effects. Structural features of this mol. scaffold are discussed regarding binding affinity and selectivity for D2-like, 5-HT1A, and 5-HT2A receptors.
After consulting a lot of data, we found that this compound(56621-48-8)Recommanded Product: 4-(Piperazin-1-yl)phenol can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem