Parsons, Andrew F. published the article 《A blockbuster synthesis for undergraduates》. Keywords: undergraduate education esomeprazole laboratory synthesis.They researched the compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9 ).Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:73590-85-9) here.
A context-based practical designed to give students the opportunity to improve their team working, communication and time-management skills was developed. By investigating the synthesis of the major antiulcer drug, esomeprazole, undergraduates are given an insight into the challenges of modern process chem., from optimization of the lead compound to its full-scale manufacture Students work as a team to prepare pyrmetazole from pyrmethyl alc. and then investigate the reaction conditions required to optimize the asym. oxidation of the sulfide group in pyrmetazole to form esomeprazole. Students do a series of small-scale oxidation reactions, using reagents and reaction conditions of their choice, to investigate how the conditions affect the efficiency of the oxidation They are required to plan their experiments to maximize the number of results they achieve over the eight-day period of the project and then provide a summary of their results and describe aspects of scaling-up their optimized reaction in individual reports, which are assessed. Their results are reviewed and compared with the current industrial process.
The article 《A blockbuster synthesis for undergraduates》 also mentions many details about this compound(73590-85-9)Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, you can pay attention to it, because details determine success or failure
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem