Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 73590-85-9, is researched, Molecular C17H19N3O2S, about High-performance liquid chromatographic assay for human liver microsomal omeprazole metabolism, the main research direction is omeprazole metabolism liver microsome determination HPLC; liquid chromatog omeprazole metabolite liver microsome.Computed Properties of C17H19N3O2S.
Assays for the measurement of omeprazole metabolites in plasma and urine were reported, but when applied to the determination of omeprazole metabolites formed by human liver microsomal incubations, there were obvious limitations in sensitivity. The present HPLC assay, which comprises extraction, evaporation and reconstitution, is several-fold more sensitive with a limit of detection of ∼ 2 pmol (2 nM in incubate) for omeprazole sulfone and 25 pmol (25 nM in incubate) for hydroxyomeprazole. Extraction efficiency is essentially quant. and is highly reproducible (coefficient of variation = 2.1% for both metabolites). The assay is linear over a wide range of concentrations and the formation of the metabolites is linear with respect to both time (to 15 min) and protein concentration (to 1.5 mg/mL). Two minor metabolites, 1 of which was identified tentatively as 5-O-desmethylomeprazole, were also formed by human liver microsomes and could be determined by this method. Preliminary studies of the formation of omeprazole sulfone and hydroxyomeprazole showed that the formation kinetics in human liver microsomes were biphasic for both metabolites, suggesting that at least 2 different cytochrome P 450 isoforms are involved in their formation.
After consulting a lot of data, we found that this compound(73590-85-9)Computed Properties of C17H19N3O2S can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem