In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, anticancer activity and molecular docking studies of new 4-nitroimidazole derivatives, published in 2021, which mentions a compound: 56621-48-8, Name is 4-(Piperazin-1-yl)phenol, Molecular C10H14N2O, Product Details of 56621-48-8.
Herein, we report the synthesis of 3-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-ylsulfanyl)-1-(4-substituted phenyl-piperazin-1-yl)-propan-1-one I [R = H, 2-F, 4-Cl, etc.] by reaction of 3-(1-benzyl-2-methyl-4-nitro-1H-imidazol-5-ylsulfanyl)-propanoyl chloride (3) with piperazine nucleophiles. Eighteen compounds were assessed for their antiproliferative inhibition potency against four human cancer cell lines (MCF-7, PC3, MDA MB231 and Du145). Compounds I [R = 2-Me, 2-OH]were the most potent anticancer agents on MCF-7 cell lines cell line with IC50 value of 1.0μg/mL, while I [R = 2-CN, 4-Cl] exhibited cytotoxic effect on PC3 and DU145 cell lines with IC50 values of 4.0 and 5.0μg/mL, resp. The mol. docking of compounds I [R = 2-Me, 2-CN, 4-Cl] was studied.
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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem