Recommanded Product: 4-(Piperazin-1-yl)phenol. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Modifications to five-substituted 3,3-diethyl-4,5-dihydro-2(3H)-furanones en route to novel muscarinic receptor ligands. Author is Bhandare, Richie R.; Canney, Daniel J..
Lead lactone-based ligands with modest affinity for muscarinic receptors were modified based on structure-activity relationship data in the literature to provide a new series of 5-substituted 4,5-dihydro-2(3H)-furanones. The modifications included the addition of various nitrogen-containing heterocycles attached to substituted and unsubstituted aromatic rings. The target compounds, e.g. I, were synthesized in modest yields and evaluated in preliminary muscarinic binding assays. A lactone-based ligand containing a diphenylmethylpiperazine moiety was identified as a nonselective muscarinic ligand with IC50 of 340 nM. The design of future ligands will be based, in part, on structure-activity data reported herein.
In some applications, this compound(56621-48-8)Recommanded Product: 4-(Piperazin-1-yl)phenol is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
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