In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and bioevaluation of 4,5,6,7-tetrahydrobenzo[d]isoxazole derivatives as melanogenesis inhibitors, published in 2014-02-20, which mentions a compound: 56621-48-8, mainly applied to arylpiperazinyl tetrahydrobenzoisoxazolyl methanone preparation melanogenesis inhibitor SAR; tetrahydrobenzoisoxalyl carboxylic acid chloride preparation arylpiperazine amide coupling, Recommanded Product: 4-(Piperazin-1-yl)phenol.
A series of 4,5,6,7-tetrahydrobenzo[d]isoxazole derivatives I [R1 = H, tert-butyl; R2 = 4-OH, 4-OMe, 2-OMe, 4-CF3, 4-F] was prepared via amide coupling of arylpiperazines with corresponding 4,5,6,7-tetrahydrobenzo[d]isoxazole carboxylic acid chlorides. Addnl., 4,5,6,7-tetrahydrobenzo[d]isoxazole derivative I [R1 = H; R2 = 4-OEt] was synthesized by O-alkylation of compound I [R1 = H; R2 = 4-OH] using iodoethane. The synthesized compounds were tested for their melanogenesis inhibiting activity through potential down-regulation of tyrosinase expression. Among the tested compounds, compounds I [R1 = H; R2 = 4-OMe, 2-OMe, 4-CF3] displayed better melanogenesis inhibiting activity than well-known compounds Arbutin and Kojic acid, without intrinsic cytotoxicity.
In some applications, this compound(56621-48-8)Recommanded Product: 4-(Piperazin-1-yl)phenol is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem