In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Design and development of 1,3,5-triazine derivatives as protective agent against spinal cord injury in rat via inhibition of NF-kB, published in 2021-06-01, which mentions a compound: 56621-48-8, mainly applied to thiazolylpyrimidinylaminotriazinyl arylpiperazinylmethylbenzamide preparation inhibitor NFkB antiinflammatory agent; spinal cord injury neuroprotectant thiazolylpyrimidinylaminotriazinyl arylpiperazinylmethylbenzamide; 1,3,5-Triazine; Inflammation; NF-κB; SCI; TLR4, SDS of cas: 56621-48-8.
Spinal cord injury (SCI) is a chronic disease causing motor and sensory loss in the affected individuals. The SCI has a huge impact on the lives of patients that makes them susceptible to life-long disability. However, the current clin. modalities are ineffective to cope the aftermath of SCI. Thus, in the present study, we aimed to develop a series of 1,3,5-triazine derivatives I (R = Cl, Br, Me, O2N, HO, MeO) as a protective agent against SCI. The mols. were developed by facile synthetic route and obtained in excellent yield. The compounds were tested for their efficacy to inhibit the transcription of NF-κB in RAW 264.7 cells, where they displayed mild to potent activity. I (R = Cl) was identified as most potent NF-κB inhibitor among the tested analogs. The effect of I (R = Cl) was further scrutinized against the SCI injury in rats induced by contusion injury. It has been found that I (R = Cl) improves motor function of rats together with reduction in inflammation and edema in spinal cord of rats. It also showed to inhibit oxidative stress and inflammation in the SCI rats. In a western blot anal., after SCI induction, I (R = Cl) inhibited NF-κB and its upstream regulator TLR4 in a dose-dependent manner. Collectively, our study provides a novel class of agent that provide protective action against SCI.
In some applications, this compound(56621-48-8)SDS of cas: 56621-48-8 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem